Table 3.
List of Clinical trials relating to various biomedical applications of hydrogel.
| Type of Hydrogel | Disease | Formulation | Study Outcome | Status | Clinical Trial Identifier |
|---|---|---|---|---|---|
| Hydroxyethyl cellulose hydrogel | Knee pain by osteoarthritis | Injection | NA | On-going | NCT04061733 |
| Polyacrylamide | Knee pain by osteoarthritis | Intra-articular injection | Clinical examination reported a transition from −7, meaning worse to 7, better on a scale of −1 to 7. | Completed | NCT03060421 |
| Polyacrylamide hydrogel and hyaluronic acid | Knee pain by osteoarthritis | Intra-articular injection | NA | On-going | NCT02763956 |
| Polyacrylonitrile hydrogel | Degenerative disc disease | Intra-discal | NA | On-going | NCT02763956 |
| Hydroxyethylcellulose hydrogel | Knee pain by osteoarthritis | Intra-articular injection | NA | On-going | NCT04061733 |
| Extracellular matrix hydrogel | Heart failure | ||||
| Alginate hydrogel | Heart failure | Intra-myocardial injection | Improved maximum oxygen uptake | Completed | NCT01311791 |
| Renal cells gelatin hydrogel | Kidney disease | Injection | Improved levels of creatinine, proteinuria, GFR | Completed | NCT02525263 |
| Renal cells gelatin hydrogel | Congenital chronic kidney disease | Injection | NA | On-going | NCT04115345 |
| Human amniotic epithelial cells hydrogel | Asherman’s syndrome | Intra-uterine injection | NA | On-going | NCT03223454 |
| Cardiac stem cells gelatin hydrogel | Ischemic cardiomyopathy | Intra-myocardial injection | Improved ventricular dysfunction | Completed | NCT00981006 |
| Radiopaque Hydrogel | Pancreatic cancer | Injection | NA | On-going | NCT03307564 |
| Biosentry Hydrogel | Pneumothorax risk after Lung biopsy procedures | Tract plug | NA | On-going | NCT02224924 |
| TraceIT hydrogel | Oropharyngeal cancer | Injection | NA | On-going | NCT03713021 |
| TraceIT hydrogel | Rectal cancer | Transperineal injection | NA | On-going | NCT03258541 |
| SpaceOAR hydrogel (PEG) | Prevention of radiation exposure to rectum in radiation therapy | Injection | Reduced adverse effects and limited radiation exposure observed in subjects | Completed | NCT01538628 |
| SpaceOAR hydrogel | Image Guided Intensity Modulated Radiotherapy for prostate cancer | Injection | Reduced rectal toxicity was observed following radiation therapy | Completed | NCT02212548 |
| TracelT hydrogel | Bladder cancer radiation therapy | Injection | Helped in locating bladder tumor during imaging process | Completed | NCT03125226 |
| VentriGel | Myocardial infarction/heart failure | Trans-endocardial injection | Parameters such as ejection fraction, end-diastolic volume and end-systolic volume were improved in myocardial infarction patients. | Completed | NCT02305602 |
| Gut Guarding Gel (alginate with calcium lactate) | Endoscopic Submucosal Dissection | Sub-mucosal injection | It enhanced the mucosa formation and reduced bleeding/tissue injury following endoscopy | Completed | NCT03321396 |
| Polyacrylamide hydrogel | urinary incontinence | Transurethral injection | The bladder retention volume was monitored and successful voiding was observed | Completed | NCT02776423 |
| Polyacrylamide hydrogel and botox | urinary incontinence | Midurethral injection | Micturitions per day increased and relief from urinary incontinence observed | Completed | NCT02815046 |
| Polyacrylamide hydrogel | Anal incontinence | Transanal injection | Reduced Wexner scores were observed after treatment | Completed | NCT02550899 |
| OTX-TKI (polyethylene glycol hydrogel with tyrosine kinase inhibitor) | Age-related Macular Degeneration | Intravitreal injection | NA | On-going | NCT03630315 |