Background: COVID19 infection is a recognized risk factor for systemic thrombosis. There have been few case reports about thrombosis following COVID19 vaccination.
Methods and Results: A middle aged lady presented with acute pulmonary thromboembolism with right ventricular dysfunction and heart failure, with history of cerebral sinovenous thrombosis 3 weeks back. Thrombophilia workup and DVT screen was negative, but on reviewing history she had received CoviShield vaccine 1 week prior to the CSVT. She was thrombolysed which was unsuccessful, and then planned for mechanical thrombectomy but died prior to the procedure.
Conclusion: COVID19 vaccine, especially those containing adenoviral particles, have an inherent predisposition to cause thrombosis by immune-mediated reactions. Although the risk is very less as compared to the benefit derived, it should be taken into account in patients who present with unexplained thrombosis post vaccination.
ABCSI21235