FIG 1.

Peptidoglycan synthesis through the elongasome is critical for fitness of LOS-deficient A. baumannii. (A) Disruption of elongasome synthesis genes and peptidoglycan remodeling genes resulted in a loss of fitness during LOS deficiency. TP and GT indicate proteins with transpeptidase and glycosyltransferase activities, respectively, to incorporate lipid II precursors into the peptidoglycan layer. (B) Peptidoglycan synthesis and remodeling genes that when disrupted had a significant (≥5-fold) loss of fitness during LOS deficiency. FC indicates fold change.