Figure 11. Publicity and breadth analysis of CD8+ T-cell receptor (TCR) β-chain features activated by SARS-CoV-2 peptide ORF1ab (MIRA55) using tcrdist3 and GLIPH2.

TCR feature publicity was determined using two methods for clustering similar TCR sequences: (A) tcrdist3-identified meta-clonotypes and (B) GLIPH2 specificity groups, sets of TCRs with a shared complementarity determining region (CDR)3 k-mer pattern uncommon in the program’s default background CD8+ receptor data. Grid fill color shows the breadth – or number of conformant clones – within the MIRA-identified clones from each patient.