Table 3.

Biodistribution and tumor/non-target ratios for 111In-SCN-Bn-DTPA-mAbs (ADC candidate, green; detection/imaging antibody, red) 72 h and 168 h post injection (p.i.)

Organ	111In-SCN-Bn -DTPA-2D7	111In-SCN-Bn -DTPA-11H9		111In-SCN-Bn -DTPA-IgG
	72 h p.i.	72 h p.i.	168 h p.i.	168 h p.i.
	(n = 4)	(n = 3)	(n = 1)	(n = 3)
Blood	6.68 ± 1.41	20.62 ± 4.33	11.06	11.37 ± 2.55
Fat	1.97 ± 0.69	1.88 ± 0.47	2.34	1.92 ± 0.99
Intestine	3.05 ± 0.40	3.25 ± 0.30	1.76	2.91 ± 1.57
Stomach	2.12 ± 0.38	2.21 ± 0.44	1.98	3.08 ± 0.55
Spleen	78.16 ± 48.53	37.84 ± 4.69	32.12	66.33 ± 22.81
Liver	18.66 ± 4.42	18.68 ± 2.22	14.41	14.60 ± 2.55
Pancreas	2.69 ± 0.53	2.95 ± 0.59	2.09	2.42 ± 0.94
Kidney	10.83 ± 2.78	12.86 ± 2.54	6.75	6.95 ± 1.20
Lungs	5.88 ± 1.52	9.54 ± 0.92	9.55	4.06 ± 2.92
Heart	5.49 ± 1.52	6.74 ± 1.04	3.50	2.40 ± 1.81
Muscle	1.87 ± 0.38	2.26 ± 0.29	1.35	1.48 ± 0.61
Bone	6.25 ± 2.98	4.46 ± 1.62	2.83	5.55 ± 2.02
Brain	0.18 ± 0.05	0.33 ± 0.04	0.20	0.25 ± 0.02
Tumor	19.09 ± 4.81	37.84 ± 4.69	35.64	14.01 ± 0.23
Tumor/muscle	19.09 ± 4.81	15.22 ± 0.64	26.38	10.47 ± 3.72

Values are presented as mean ± SD where possible.