Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Correction to: Cell Discovery (2021) 7:103

10.1038/s41421-021-00341-7, Published online 31 October 2021

In the initial published version of this article¹, we missed some errors while proofreading the manuscript for the publication. The statistical values in Abstract and Results sections were inconsistent with those in Table 1. Upon careful examination of our original data, the second sentence in Abstract section should be “Here, we performed a two-stage genome-wide association study (GWAS) with a total sample of 1478 homosexual males and 3313 heterosexual males in Han Chinese populations and identified two genetic loci (rs17320865, Xq27.3, FMR1NB, P_meta = 7.61 × 10⁻⁹, OR = 1.31; rs7259428, 19q12, ZNF536, P_meta = 8.20 × 10⁻¹⁵, OR = 0.65) showing consistent association with male sexual orientation.” On page 2, the second column, the lines 28–35 should be “All four SNPs showed consistent association in the independent validation samples, and two SNPs reached a genome-wide significance level (P < 5 × 10⁻⁸) after meta-analysis, including SNP rs7259428 on chromosome 19q12 (located in ZNF536, P = 8.20 × 10⁻¹⁵, OR = 0.65; Fig. 1e and Table 1) and rs17320865 on chromosome Xq27.3 (located in FMR1NB, P = 7.61 × 10⁻⁹, OR = 1.31; Fig. 1d and Table 1).” In Table 1, the gene symbol ‘ZNF356’ should be ‘ZNF536’. The corrected version of the Table 1 is displayed below.

Table 1.

Evidence of an association of the four SNPs in a two-stage GWAS in Han Chinese population.

					Discovery stage (521 homosexual and 1270 heterosexual men)			Replication stage (957 homosexual and 2043 heterosexual men)			Meta-analysis (1478 homosexual and 3313 heterosexual men)
SNP	CHR	BP	A1/A2	Gene	OR	SE	P	OR	SE	P	OR	P	P_Het
rs17320865	X	147085464	A/T	FMR1NB	1.39	0.07	9.77 × 10−6	1.26	0.06	8.81 × 10−4	1.31	7.61 × 109	0.30
rs7259428	19	31104579	G/A	ZNF536	0.67	0.09	3.87 × 10−6	0.64	0.07	1.13 × 10−6	0.65	8.20 × 1015	0.69
rs12039940	1	181952711	C/T	ZNF648	1.57	0.10	9.22 × 10−6	1.01	0.04	8.72 × 10−1	1.07	6.28 × 102	1.0 × 10−4
rs7500300	16	5932886	C/T	RBFOX1	1.45	0.08	5.28 × 10−6	1.11	0.05	6.84 × 10−2	1.19	3.08 × 10−5	5.2 × 10−3

CHR chromosome, OR odds ratio, ORs were calculated according to the minor allele, A1/A2 minor/major allele, P_Het p values of heterogeneity test.