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. 2021 Nov 17;600(7887):133–137. doi: 10.1038/s41586-021-04111-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Residues are numbered based on the ORF1a/b absolute amino acid position in the reference sequence JQ065043 (pig/China). a, Amino acid signature pattern analysis on ORF1a/b. CN, China; SEA, southeast Asia. b, The trimer structure of the spike glycoprotein. Different colours are assigned to each monomer: red indicates residue 550, where Haitian sequences have a valine to alanine mutation.