Capstick TGD, Hopkinson NS. Int J Chron Obstruct Pulmon Dis. 2021;16:2917–2923.
The authors have advised there are minor errors in Table 2 on pages 2920–2921. The correct Table 2 is as follows.
Table 2.
Potential Alternatives to Inhalers for COPD and Asthma That are Not Associated with Vectura
| Brand Name | Generic Drugs | Licence | Manufacturer/Partners | Alternative Options |
|---|---|---|---|---|
| Flutiform pMDI | Fluticasone Propionate/Formoterol | Asthma | Kyorin MundiPharma | No alternatives in same drug combination. Alternatives in pMDI include ● Beclometasone/formoterol (Fostair®, Luforbec®) ● Fluticasone propionate/salmeterol (AirFluSal®, Aloflute®, Combisal®, Sereflo®, Seretide®, Sirdupla®) - NB. Not all brands available in low, medium and high dose ICS. ● Budesonide/formoterol (Symbicort®). NB. Only available in two strengths (low and medium dose), and with HFA 227 propellant with a very high carbon impact. |
| Flutiform K-haler | Fluticasone Propionate/Formoterol | Asthma | MundiPharma | Flutiform K-haler discontinued in UK April 2021. No ICS/LABA available in breath-actuated pMDI devices. For alternatives in pMDI, see Flutiform pMDI, above. |
| Ultibro Breezhaler | Indacaterol/glycopyrronium | COPD | Novartis | DPI alternative: ● Duaklir Genuair (formoterol/aclidinium) Aerosol alternatives: ● Bevespi Aerosphere pMDI (formoterol/glycopyrronium) ● Spiolto Respimat (olodaterol/tiotropium) |
| Seebri Breezhaler | Glycopyrronium | COPD | Novartis | DPI alternative: ● Eklira Genuair (aclidinium) ● Tiotropium (Spiriva® HandiHaler, Braltus® Zonda, Tiogiva® MRX003-R inhaler, Acopair® NeumoHaler) Aerosol alternative: ● Spiriva Respimat (tiotropium) |
| Enerzair Breezhaler | Mometasone/Indacaterol/glycopyrronium | Asthma | Novartis | There are no alternative ICS/LABA/LAMA DPI inhalers licensed for use in asthma. DPI alternatives would require use of a suitable ICS/LABA DPI in combination with Spiriva Respimat (the only licensed LAMA for asthma). Aerosol alternative: ● Trimbow MDI (beclometasone/formoterol/glycopyrronium). NB. Trimbow is licensed in asthma as a medium dose ICS, whilst Enerzair is a high dose ICS, so a switch would represent an ICS dose reduction. |
| AirFluSal Forspiro | Fluticasone Propionate/Salmeterol | Asthma, COPD | Sandoz | Alternative DPIs include: ● Fluticasone propionate/salmeterol DPIs: Seretide® Accuhaler, Fixkoh® Airmaster, Fusacomb® Easyhaler, Stalpex® G7 inhaler Alternative DPIs for other ICS/LABA drugs include: ● Budesonide/formoterol: DuoResp® Spiromax, Fobumix® Easyhaler, Symbicort® Turbohaler ● Beclometasone/formoterol: (Fostair® NEXThaler) |
| AirBuFo Forspiroa | Budesonide/formoterol | Asthma, COPD | Sandoz | Not licensed in the UK. Alternative DPIs include: ● Budesonide/formoterol: DuoResp® Spiromax, Fobumix® Easyhaler, Symbicort® Turbohaler Alternative DPIs for other ICS/LABA drugs include: ● Beclometasone/formoterol: (Fostair® NEXThaler) ● Fluticasone propionate/Salmeterol DPIs: Seretide® Accuhaler, Fixkoh® Airmaster, Fusacomb® Easyhaler, Stalpex® G7 inhaler |
| Fluticasone Propionate and Salmeterolb | Fluticasone Propionate/Salmeterol | Asthma, COPD | Hikma | Not licensed in the UK. Alternative DPIs include: Fluticasone Propionate/Salmeterol DPIs: Seretide® Accuhaler, Fixkoh® Airmaster, Fusacomb® Easyhaler, Stalpex® G7 inhaler |
| Breelibc | Nebuliser for adminstration of Ventavis (iloprost), or generic Iloprost Zentiva | Pulmonary Hypertension | Bayer | No other licensed iloprost nebuliser solution preparations available |
| Incruse Ellipta | Umeclidinium | COPD | GSK | DPI alternative: ● Eklira Genuair (aclidinium) ● Tiotropium (Spiriva® HandiHaler, Braltus® Zonda, Tiogiva® MRX003-R inhaler, Acopair® NeumoHaler) Aerosol alternative: ● Spiriva Respimat (tiotropium) |
| Anoro Ellipta | Vilanterol/Umeclidinium | COPD | GSK | DPI alternative: ● Duaklir Genuair (formoterol/aclidinium) Aerosol alternatives: ● Bevespi Aerosphere pMDI (formoterol/glycopyrronium) ● Spiolto Respimat (olodaterol/tiotropium) |
| Relvar/Breo Ellipta | Fluticasone furoate/vilanterol | Asthma, COPD | GSK | No alternatives in same drug combination. DPI alternatives: ● Fluticasone propionate/salmeterol DPIs: Seretide® Accuhaler, Fixkoh® Airmaster, Fusacomb® Easyhaler, Stalpex® G7 inhaler ● Budesonide/formoterol: DuoResp® Spiromax, Fobumix® Easyhaler, Symbicort® Turbohaler ● Beclometasone/formoterol: (Fostair® NEXThaler) |
| Trelegy Ellipta | Fluticasone furoate/vilanterol/umeclidinium | COPD | GSK | DPI alternative: ● Trimbow NEXThaler (beclometasone/formoterol/glycopyrronium). Available from September 2021. Aerosol alternativies: ● Trimbow MDI (beclometasone/formoterol/glycopyrronium) ● Trixeo Aerosphere pMDI (budesonide/formoterol/glycopyrronium) |
Notes: aAirBuFo Forspiro is authorised in a number of Member States of the EEA, including Belgium, Denmark, France, Ireland, Italy, Norway, Portugal, Spain, Sweden. bHikma Pharmaceuticals plc announced that they had resumed the launch of a generic version of Advair diskus in the US.9 cBreelib is a nebuliser approved for the administration of iloprost (Ventavis®) and generic Iloprost Zentiva nebuliser solution to adult patients with primary pulmonary hypertension. The table is illustrative, and the alternatives suggested are based on UK prescribing. Given local availability and licensing the range of options may be different in other countries.
The authors apologize for these errors and advise they do not affect the results of the paper.