Figure 3.

Cardiac Magnetic Resonance changes in a patient with Familial Hypercholesterolemia. This figure shows CMR findings of an asymptomatic HeFH patient with subendocardial myocardial infarction (upper figure) compared to a healthy control (lower figure). Red arrows point at the damaged area, evidenced by LGE and T1 mapping.

T1 mapping is a new measure of myocardial fibrosis with CMR, where a parametric reconstructed image of the myocardium is obtained. Each pixel's intensity corresponds to the T1 relaxation time of the corresponding myocardial voxel. Late gadolinium enhancement (LGE): the increase in gadolinium concentration within fibrotic tissue causes T1 shortening, which appears as bright signal intensity in the CMR image. CMR, Cardiac Magnetic Resonance; HeFH, Heterozygous Familial Hypercholesterolemia.