Table 3.

Disease activity and damage in JSLE with a neuropsychiatric involvement. For ACR score, mean, and range are shown for total JSLE cohort, mean (SD) are shown for subgroups to be statistically analyzed. ACR scores are counted up to the time of that visit.

	All JSLE patients	JSLE patients with NP involvement	JSLE patients without NP involvement	p value	JSLE patients with early NP involvement	JSLE patients with late NP involvement	p value
ACR score at first visit	4.7 (2–9)	4.9 (1.5)	4.6 (1.2)	0.07	5 (1.5)	4.8 (1.4)	0.34
ACR score at last visit	5.6 (4–10)	6 (3.3)	5.5 (1.3)	<0.001	6.3 (1.8)	5.8 (1.4)	0.09
Global BILAG score (mean) at first visi	10.2	13.4	9.2	<0.001	15.2	11.7	0.1
Global BILAG score (mean) at last visit	2.7	3.1	2.6	0.27	3.8	2.5	0.1
SLICC damage score (mean) at first visit	0.2	0.3	0.2	0.02	0.6	0	0.01
SLICC damage score (mean) at last	0.6	1.2	0.4	<0.001	1.7	0.7	0.009

ACR: American College of Rheumatology; BILAG: British Isles Lupus Assessment Grade; SLICC: Systemic Lupus International Collaborating Clinic damage index; NP: neuropsychiatric; JSLEs: juvenile systemic lupus erythematosus. ACR, global pBILAG2004, and SLICC damage index scores at the first and last visit, distinguishing JSLE patients with and without NP involvement, as well as those with NP involvement already at first visit (“early” NP) respect to those that develop it later (“late” NP). SD, standard deviation. For continuous variables, Mann–Whitney U test was used; for categorical variables, Chi-square test was used.