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. 2021 Sep 14;77(1):111–117. doi: 10.1111/all.15065

TABLE 1.

Kinetic parameters for the RBD‐ACE2 interaction calculated by BLI

Analyte* KD [M] kon [M−1s−1] koff [s−1] R 2
RBDWT 21.3 × 10−9 1.5 × 105 3.2 × 10−3 0.9926
RBDE484K 19.7 × 10−9 1.6 × 105 3.1 × 10−3 0.9957
RBDL452R/E484Q 4.6 × 10−9 7.2 × 105 3.3 × 10−3 0.9934
RBDN440K 9.9 × 10−9 3.1 × 105 3.1 × 10−3 0.9954

*RBDWT=Receptor‐Binding Domain wild type, *RBDL452R/E484Q= Receptor‐Binding Domain L452R, E484Q mutations, *RBDE484K= Receptor‐Binding Domain E484K mutation, *RBDN440K= Receptor‐Binding Domain N440Kmutation.