Letter to the editor: “Autoimmune hepatitis after COVID‐19 vaccination”

To the editor,

We would like to correspond on the issue of autoimmune hepatitis (AIH) following COVID‐19 vaccination.^{[ 1 ]} Palla et al. discuss the possible association between AIH and COVID‐19 vaccination.^{[ 1 ]} Adverse effects of the vaccine are possible, and liver problems following vaccination present an interesting clinical problem. Some researchers propose that an abnormal immune response is the definitive cause of AIH.^{[ 2 ]} However, it is usually hard to definitively state that AIH is induced by a vaccine. Almost all reported cases lack prevaccination laboratory data, and it is not possible to exclude the existence of prevaccination autoimmunity. Also, there is usually no complete investigation for other causes of hepatitis. Additionally, the AIH might be a coincidence. Coincidence of a medical problem after COVID‐19 vaccination and differential diagnosis is hard. For example, dengue can co‐occur in a vaccine recipient and cause platelet and liver problems.^{[ 3 ]} After vaccination, there is also the possibility of excessive blood viscosity,^{[ 4 ]} which might also be a trigger factor for liver problems.^{[ 5 ]}

CONFLICT OF INTEREST

Nothing to report.