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. 2021 Nov 15;10:e73753. doi: 10.7554/eLife.73753

Figure 9. Water extract of Gastrodia elata Blume (WGE) treatment rescues impaired locomotion of LRRK2-G2019S mice.

Figure 9.

(A) Video-tracked paths for nTg, LRRK2-G2019S, and WGE-fed LRRK2-G2019S mice (8.5 and 11.5 months old) during the open-field test. (B) Quantification of total distance (m), average velocity (cm/s), and percentage moving time for 8.5-, 9.5-, 10.5-, and 11.5-month-old mice. (C) Captured and converted images of single stance for each paw of 11.5-month-old nTg, LRRK2-G2019S, and WGE-fed LRRK2-G2019S mice in a catwalk analysis. (D) Quantification of stride length for each paw of 8.5- and 11.5-month-old mice. Data in (B) and (D) are presented as mean ± SEM (nTg; N = 5, G2019S; N = 6, WGE-fed G2019S; N = 6). One-way ANOVA and Tukey’s post-hoc multiple comparison test: *p<0.05, **p<0.01, ***p<0.001, ns, not significant. RF, right front; RH, right hind; LF, left front; LH, left hind.