TABLE 4.
Spike protein mutations in variants of concern and variants of interest
| Variants of concern | ||||
|---|---|---|---|---|
| WHO label | Lineage + additional mutations | Country first detected (community) | Spike mutations of interest | Year and month first detected |
| Beta | B.1.351 | South Africa | K417N, E484K, N501Y, D614G, A701V | September 2020 |
| Gamma | P.1 | Brazil | K417T, E484K, N501Y, D614G, H655Y | December 2020 |
| Delta | B.1.617.2 | India | L452R, T478K, D614G, P681R | December 2020 |
| Variants of interest | ||||
| n/a | B.1.620 | Unclear | S477N, E484K, D614G, P681H | February 2021 |
| Mu | B.1.621 | Colombia | R346K, E484K, N501Y, D614G, P681H | January 2021 |
| Lambda | C.37 | Peru | L452Q, F490S, D614G | December 2020 |
Note: The data are taken from European Center for Disease Prevention and Control (https://www.ecdc.europa.eu/en/covid‐19/variants‐concern). n/a: no WHO label has been assigned to this variant (accessed on October 6, 2021).