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. 2021 Nov 22;143(48):20377–20383. doi: 10.1021/jacs.1c09975

Asymmetric Full Saturation of Vinylarenes with Cooperative Homogeneous and Heterogeneous Rhodium Catalysis

Haibo Wu †, Jianping Yang †, Bram B C Peters †, Luca Massaro †, Jia Zheng †, Pher G Andersson †,‡,*
PMCID: PMC8662739  PMID: 34807592

Abstract

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Homogeneous and heterogeneous catalyzed reactions can seldom operate synergistically under the same conditions. Here we communicate the use of a single rhodium precursor that acts in both the homogeneous and heterogeneous phases for the asymmetric full saturation of vinylarenes that, to date, constitute an unmet bottleneck in the field. A simple asymmetric hydrogenation of a styrenic olefin, enabled by a ligand accelerated effect, accounted for the facial selectivity in the consecutive arene hydrogenation. Tuning the ratio between the phosphine ligand and the rhodium precursor controlled the formation of homogeneous and heterogeneous catalytic species that operate without interference from each other. The system is flexible in terms of both the chiral ligand and the nature of the external olefin. We anticipate that our findings will promote the development of asymmetric arene hydrogenations.

Introduction

Catalysis plays a fundamental and key role in organic synthesis and is used as a tool for the production of numerous pharmaceuticals, natural products, agrochemicals, and fine chemicals.1,2 Homogeneous and heterogeneous catalyzed hydrogenation constitute two well-developed areas in both industry and academia and have independently been awarded shares of Nobel prizes (1912, Sabatier; 2001, Noyori and Knowles).3−5 Over the past decades, rhodium has emerged as a robust metal for homogeneous as well as heterogeneous catalyzed hydrogenation. The development of chiral ligands (mainly diphosphines) that in many cases are commercially available presently has driven and expanded homogeneous rhodium-catalyzed hydrogenation of diversely substituted olefins largely to become a powerful strategy for the production of optically active compounds (Figure 1a).6,7 On the other hand, heterogeneous rhodium catalysts have been found to be reactive toward the hydrogenation of aromatic unsaturated bonds and applied therein (Figure. 1b).8 However, asymmetric hydrogenation of aromatic compounds is restricted to heteroaromatic rings and fused arenes, whereas the asymmetric hydrogenation of simple substituted benzenes remains a formidable goal.9−12 This is mainly attributed to the relatively high resonance stability of all-carbon aromatic rings compared to the hetero- or fused- aromatic ring systems. Despite the reduction of arenes having been known for many decades, no chiral catalyst is known for the asymmetric hydrogenation of simple substituted arenes; yet, it is highly sought after. Traditionally, the hydrogenation of arenes is achieved by using solid supported heterogeneous rhodium catalysts.13 In recent years, homogeneous precursors are more frequently used as an alternative that can form nanoparticles under the reaction conditions.14−21 These nanoparticles showed higher reactivity and a larger functional group tolerance compared to solid supported metal catalysts. To date, a clear separation between homogeneous and heterogeneous rhodium-catalyzed hydrogenation exists. Ideally, the advances in both fields of catalysis combined could tackle the asymmetric hydrogenation of arenes that remains a largely unsolved bottleneck in state-of-the-art hydrogenation.

Figure 1.

Figure 1

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Rhodium-catalyzed hydrogenation of olefins and aromatic rings. (a) Homogeneous rhodium-catalyzed asymmetric hydrogenation of olefins. (b) Heterogeneous rhodium-catalyzed hydrogenation of aromatic rings. (c) This work: Asymmetric dearomative hydrogenation with cooperative homogeneous and heterogeneous rhodium catalysis.

Dearomative transformations, reactions able to break and functionalize the π-system in aromatic compounds, are of high interest.22,23 In particular the pharmaceutical industry stands to benefit since it allows late-stage introduction of complex structural diversity into lead compounds.24 Most importantly, aromatic precursors are readily accessible, and various methodologies targeting aromatic sp2-hybridized carbons have been developed.25 Therefore, dearomatization offers a direct opportunity to escape flat land out of relatively simple and abundant starting materials. A convenient and atom efficient strategy would be to use molecular hydrogen for this purpose. This hydrogenative strategy would largely increase in value if used in an asymmetric fashion since it is known that stereoisomers often exhibit different pharmacological properties.26 Here we communicate the use of diphosphine ligands in combination with common rhodium precursors for the asymmetric full saturation of vinylarenes that operates via cooperative homogeneous and heterogeneous catalysis (Figure 1c). This protocol offers a very flexible and conceptionally novel approach that relies on a dual system: an irreversible binding between diphosphine and rhodium, a very efficient ligand accelerated asymmetric hydrogenation of an olefin, and the in situ aggregation of nonligated rhodium into a very active nanoparticle for the hydrogenation of the aromatic ring that results in the facile construction of chiral cyclohexane motifs.

Results and Discussion

Discovery of the Duality of [Rh(COD)2]BF4

Seeking the development of an asymmetric hydrogenation of arenes, initial studies on the reactivity of rhodium catalysts demonstrated that common rhodium precursors in the form of [Rh(COD)2]X (X = anion) aggregate into very reactive nanoparticles for the hydrogenation of substituted benzenes (Figure 2a). We realized that the exact same precursors are frequently used for the homogeneous rhodium-diphosphine-catalyzed asymmetric hydrogenation of olefins, which is one of the most studied types of asymmetric hydrogenation.6,27 Notably, although some neutral rhodium complexes (such as [Rh(COD)Cl]228 and [Rh(η5-C5Me5)Cl2]229,30) were found as effective precatalysts for dearomative (transfer) hydrogenations, the duality of commonly used cationic rhodium precursors ([Rh(COD)2]X) has not been reported so far. The active catalyst in these homogeneous asymmetric hydrogenations is normally formed in situ by mixing a rhodium-precursor and diphosphine ligand. Usually, a slight excess of ligand is used to ensure full complexation of all monomeric rhodium and thus prevent a racemic background reaction by nonligated catalyst. The very strong binding affinity between rhodium and diphosphine ligands makes ligation practically irreversible and prevents the persistence of nonligated rhodium monomers.31 We anticipated that a single rhodium precursor can simultaneously form both chiral homogeneous complexes and the heterogeneous nanoparticles.32 Our envisioned strategy would use an excess of rhodium precursors to direct the hydrogenation of arenes by first forming a stereogenic center by an enantioselective hydrogenation of styrenic olefins.

Figure 2.

Figure 2

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Development of arene hydrogenation based on classical Rh/diphosphine system. (a) Discovery of the duality of [Rh(COD)2]BF4 as the active catalyst for olefin/arene hydrogenation. (b) Kinetics of olefin hydrogenation. The green line refers to the total amount of 2a and 3a. (c) Kinetics of arene hydrogenation.

Kinetic Studies

First, kinetic experiments were performed to study the relative reactivity of the catalytic homogeneous and heterogeneous species. The hydrogenation of the olefin was monitored first (Figure 2b). Using [Rh(COD)2]BF4 as the catalyst, an induction period was observed and the hydrogenation started after a period of 12–15 min (green line). From this point hydrogenation proceeded gradually to reach 45% of 2a in 2 h. A large rate acceleration of the hydrogenation was observed when [Rh(COD)2]BF4 and the diphosphine L1 were used in an equimolar ratio and under these conditions hydrogenation was complete in 15 min and gave rise to the product in high stereoselectivity (blue line, 99% ee). Intriguingly, using [Rh(COD)2]BF4 and L1 in a 2:1 ratio, full conversion and 99% ee was again reached within 15 min (red line). These observations demonstrate that rhodium catalyzed hydrogenation of olefins is a very efficient form of ligand accelerated catalysis33 in which the addition of a diphosphine ligand leads to an enormous rate acceleration (k1 ≫ k0, Figure 1c). Since no loss in enantioselectivity was observed when using a sub stoichiometric amount of ligand, it was demonstrated that the ligand accelerating effect using L1 is of a sufficient magnitude to completely outperform the hydrogenation by nonligated rhodium particles that will not interfere with asymmetric olefin hydrogenation. The relatively low reactivity of [Rh(COD)2]BF4 compared to that of [Rh(COD)2]BF4 and L1 (2:1) indicates that the [Rh(COD)(solvent)2]BF4 complex is stabilized by styrenes and forms nanoparticles more easily once the styrenic olefin has been reduced.

Next, the hydrogenation of the aromatic ring was monitored using rac-2a as the substrate (Figure 2c). The Rh-L1 complex did not catalyze the hydrogenation of the aromatic ring (blue line) whereas 4 mol % of [Rh(COD)2]BF4 alone gave rise to a fast reaction and full conversion in 3 h (green line). A control experiment was carried out doping the reaction with benzothiophene (see the SI) that inhibit the reaction and demonstrated that the arene hydrogenation involves heterogeneous catalysis.34 The in situ formation of heterogeneous Rh-nanoparticles was further confirmed by HR-TEM images (Figure S3). Interestingly, 8 mol % of [Rh(COD)2]BF4 together with 4 mol % L1 hydrogenates arene significantly slower (red line, 73% conversion in 5 h) as compared to 4 mol % of [Rh(COD)2]BF4 alone (full conversion in 3 h). Many studies demonstrated that the presence of phosphine ligands in solution affects the nanoparticle properties and thus can alter the reactivity toward arene hydrogenation.35−38 The kinetic data suggests that both the olefin and the arene hydrogenation are two separate processes that can cooperate as a result of ligand binding and ligand accelerated catalysis.

Evaluation of Rh-Precursors and the Generality of Diphosphine Ligands

Based on the understanding of the kinetics of both olefin and arene hydrogenation processes, we then proceeded to explore the potential of the well-established Rh/diphosphine system for the asymmetric dearomative hydrogenation. First, a series of commonly used rhodium precursors were tested for the hydrogenation of compound 4a that is normally used as a benchmark substrate for the rhodium-catalyzed asymmetric hydrogenation of olefins (Table 1). This olefin was completely hydrogenated in all cases and in addition, the aromatic ring was reduced to a varying extent (entries 1–6, 23–86% of 6a). [Rh(COD)2]BF4 and [Rh(COD)2]SbF6 were found to be most reactive catalysts and formed 6a in 85% and 86% yield respectively (entries 2 and 4). Addition of a slight excess of L2 (1.1 equiv) to the hydrogenation produced exclusively 5a in 99% ee, as anticipated (entry 7). Intriguingly, we found that 6a could be formed in the exact same enantioselectivity as 5a is formed by using a well-chosen 2:1 ratio between the rhodium precursor and L2 (entries 8–13). To our delight, full conversion toward 6a in 99% ee was obtained when [Rh(COD)2]BF4 and [Rh(COD)2]SbF6 were used as rhodium precursors (entries 9 and 11). Thus, nonligated rhodium can be present in solution without interference in the olefin hydrogenation. Most important, the same precursor also forms a reactive catalyst for the hydrogenation of arenes that allows the formation of optically pure saturated cyclohexanes. In a control experiment (entry 14), Rh on carbon was used instead of the in situ generated Rh-nanoparticles, a significant decrease of enantioselectvity (79% ee) was observed.

Table 1. Evaluation of Rh Precursorsa.

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a

The reactions were carried out with 4a (0.05 mmol) in 1.0 mL of i-PrOH at room temperature. Conversions (conv.) were determined by 1H NMR spectroscopy. Enantiomeric excesses (ee) were determined by GC analysis using chiral stationary phase.

In principle, any Rh/diphosphine catalyzed hydrogenation of olefins can be followed up with the consecutive hydrogenation of the arene using this concept. The generality in terms of chiral ligand was demonstrated using structurally diverse diphosphine ligands39 (Table 2). When L2 was used in a 1:1 ratio with [Rh(COD)2]BF4, 4a was fully converted to 5a in 99% ee (entry 1). The arene was also hydrogenated when the Rh:L2 ratio was increased to 2:1 and product 6a was obtained in a clean manner (entry 2, 99% ee). The hydrogenation of 4a to either of the products proceeded also in 99% ee when L3 and L4 were used (entries 3–6). Even though L5 and L6 produced 6a in a lower enantiomeric excess compared to L2-4 (entries 7–10), using the conditions developed herein, still produced 6a in the same range of ee as 5a.

Table 2. Generality of Diphosphine Ligandsa.

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a

The reactions were carried out with 4a (0.05 mmol) in 1.0 mL of i-PrOH at room temperature. Conversions were determined by 1H NMR spectroscopy. Enantiomeric excesses (ee) were determined by GC analysis using chiral stationary phase.

Evaluation of Substrate Classes

With the proof of concept established, various acyclic and cyclic substituted benzene substrate classes including di-, tri-, and tetra-substituted olefins were evaluated (Scheme 1). Starting with acyclic terminal olefins, electron-donating groups and electron-withdrawing groups in the para-position were found to be compatible and the corresponding fully saturated acetamides (6b-e) were formed in excellent yield with 92–99% ee and 76/24–90/10 d.r.. Both arenes were reduced with excellent enantioselectivity when benzamide derived enamides 4f–g (80/20–86/14 d.r.) or pyridine-substituted olefin 4h (55/45 d.r.) were hydrogenated. The meta-substituted substrate 4i was fully reduced in 99% ee but with a poor diastereoselectivity. The ortho-substituted terminal enamide 4j was also evaluated, however, this substrate was found to be much slower in the olefin hydrogenation step. It was known40 that the enantiocontrol in the hydrogenation of ortho-substituted terminal enamides is challenging and requires specialized ligands, 89% ee and 88/12 d.r. were achieved by using a bidentate phosphine-phosphoramidite ligand L9(41) with a two-step procedure. Notably, this strategy might be further applied as a possible alternative to the chiral auxiliary approaches.42−44 Then, numerous trisubstituted olefins that bear the prochiral center either in the benzylic or homobenzylic position were hydrogenated and formed the desired products in high stereoselectivities and yields (6k-p). To our delight, tetrasubstituted enamide 4q was also hydrogenated in high enantioselectivity. The diastereoselectivity in the heterogeneous dearomative hydrogenation is highly substrate dependent. Encouraged by the excellent enantioselectivities obtained, we proceeded in evaluating substrates bearing cyclic olefins that have been reduced in higher diastereoselectivity in previous studies.45,46 Different nitrogen- and oxygen 3-substituted 1H-indenes were well tolerated (1a-e). The facial selectivity in the hydrogenation of the cyclic arene is sterically controlled, and as a result more sterically demanding groups in the benzylic position ensured higher diastereomeric ratio (3a-c) (from 66/34 to 82/18). Interestingly, trifluoromethyl-enamides 3d were found to induce even higher diastereoselecitvities (93/7). Indenes bearing a tetrasubstituted olefins (1f-g) as well as a substitution in the 4-, 5- or 6-position (1h-k) were also smoothly hydrogenated and produced products with 4 stereogenic centers in excellent stereocontrol (up to 99/1 d.r. and 99% ee). Diverse six-membered fused arenes 1i-r yielded the desired product in high isolated yields and good stereoselectivities. Carbon–oxygen bond cleavage was observed during the hydrogenation of cyclic enol-esters that accounted for the decreased yields.

Scheme 1. Evaluation of Substrate Classes.

Scheme 1

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Reaction conditions: substrate (0.2 mmol), 3 mol % ligand and 8 mol % [Rh(COD)2]SbF6 in i-PrOH (2.0 mL) under 50 bar H2 at room temperature for 24 h. Isolated yield. Enantiomeric excesses and diastereomeric ratios were determined by GC analysis using chiral stationary phase.

Additional [Rh(COD)2]SbF6 (5 mol %) was added after 12 h, then 50 bar H2 for 12 h.

2 mol % ligand and 2 mol % [Rh(COD)2]SbF6 were used in CF3CH2OH (2.0 mL) under 10 bar H2 for 12 h, then 5 mol % [Rh(COD)2]SbF6 was added under 50 bar H2 for 12 h.

10 bar H2.

[Rh(COD)2]BF4 was used instead of [Rh(COD)2]SbF6.

Scale-up Asymmetric Full Saturation of Vinylarene and Applications

The hydrogenation of 1f was performed on a gram-scale to produce 3f in high yield as a single stereoisomer, showing the scalability of this protocol (Scheme 2). Compound 1d could also be hydrogenated on a gram-scale and consecutive cleavage of the amide group provided 7 as an all-sp3 carbon analogue to the widely used 1-aminoindane motif in pharmaceuticals.47 The reaction of 7 with propargyl bromide yielded the arene saturated analogue 8 to the anti-Parkinson’s therapeutic Rasagiline48 in good yield. Analysis of large data sets on medicinal bioisosters in previous literature correlates both increased sp3-content and the number of stereogenic centers with the enhanced likelihood that lead compounds proceed to clinical trials.49,50 Given this knowledge, the methodology presented herein can grant access to chiral cyclohexane scaffolds and thus positively influence both factors in an efficient and atom-economical way.24,51

Scheme 2. Gram Scale Reaction and Applications.

Scheme 2

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Conclusions

In summary, the results presented herein suggest that the developed protocol shows potential for application of the well-established classical homogeneous rhodium catalytic system to the formidable asymmetric arene hydrogenation and demonstrate the power of merging homogeneous and heterogeneous catalysis in organic synthesis. It is also anticipated that this practical dearomative hydrogenation will be of interest to the pharmaceutical industry for the rapid buildup of the complexity in the lead compounds from abundant aromatic feedstocks.

Acknowledgments

The authors are grateful to the Swedish Research Council (VR), the Knut and Alice Wallenberg foundation (KAW 2016:0072 & KAW 2018:0066) and Stiftelsen Olle Engkvist Byggmästare for their financial support. We thank Zhehao Huang (MMK, Stockholm University) for HR-TEM images analysis. We also thank Byron K. Peters and Mark D. Nolan for helpful discussions and proof reading of the manuscript.

Supporting Information Available

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/jacs.1c09975.

  • Materials, experimental procedures, characterization data for all new compounds, assignment of the absolute configurations of complete hydrogenated products, additional experiments, HR-TEM images of in situ generated Rh-nanoparticles, and NMR and GC spectra (PDF)

Author Contributions

§ H.W. and J.Y. contributed equally.

The authors declare no competing financial interest.

Supplementary Material

ja1c09975_si_001.pdf (12MB, pdf)

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