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. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: Cell. 2021 Jun 21;184(15):3998–4015.e19. doi: 10.1016/j.cell.2021.05.027

Figure 5. Treg cells self-regulate their intratumoral population size via CTLA-4 in trans.

Figure 5.

(A) Experimental protocol.

(B) CTLA-4 expression in CD45.2+ Ctla4f/f or control Treg cells in the TME following tamoxifen treatment.

(C and D) Expression of Ki67 (C) and frequency (D) of CTLA-4-sufficient (n = 8) or CTLA-4-deficient (n = 7) CD45.2+ Treg cells in the TME (pooled from two experiments). Fold change as compared to control groups indicated in parentheses. MFI was normalized by the mean of control groups. p values calculated by Mann-Whitney U test.

See also Figure S6.