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. Author manuscript; available in PMC: 2022 Dec 14.
Published in final edited form as: Circulation. 2021 Sep 30;144(24):1899–1911. doi: 10.1161/CIRCULATIONAHA.121.056456

Figure 1: Meta-Analyses Evaluating Associations Between 5 Epigenetic Age Acceleration Measures and Incident Atrial Fibrillation.

Figure 1:

Analyses adjusted for chronological age, sex, race, smoking variables, and technical factors. (A) Horvath clock, (B) Hannum clock, (C) DNAm PhenoAge clock, (D) DNAm PAI-1 epigenetic predictor, (E) DNAm GrimAge clock.

HRs are per 5-year increment in each age measure, per standard deviation increment for DNAm PAI-1.

Technical factors include cell types, sample batch, laboratory site, and follow-up visit.

CI = confidence intervals, FHS = Framingham Heart Study, ARIC = Atherosclerosis Risk in Communities, CHS = Cardiovascular Health Study.

Tests for overall effect heterogeneity performed with the Q- and I-squared statistics.