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. 2021 Dec 14;97(24):e2404–e2413. doi: 10.1212/WNL.0000000000012945

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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(A and C) Correlations between age and (A) CSF neurofilament light (NfL) and (C) serum NfL. (B and D) Correlations between expanded CAG repeat length and (B) CSF NfL and (D) serum NfL. Correlations are represented by r and p values generated from Spearman rank correlation. The r and p values were generated from either controls only (gray) or individuals with spinocerebellar ataxia type 2 (SCA2) (colored) only. Only individuals with SCA2 were included in the association between expanded CAG repeat length and NfL because controls do not carry expanded CAG repeat.