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. 2021 Dec 14;97(24):e2404–e2413. doi: 10.1212/WNL.0000000000012945

Figure 3. Serum NfL Levels of Controls and Individuals With SCA2 in Group B and Receiver Operating Characteristic Curves for Discrimination.

Figure 3

(A and B) Serum neurofilament light (NfL) and residual serum NfL were higher in those with manifest spinocerebellar ataxia type 2 (SCA2) than in controls and individuals with preclinical SCA2 (preSCA2) and higher in those with preSCA2 than in controls. Residuals were generated from the regression of serum NfL on age representing the component of serum NfL not explained by age. NfL levels and residual NfL levels are shown by boxplots with Tukey whiskers. NfL values were natural log-transformed for statistical analyses and are displayed geometrically. The p values were generated from multiple linear regressions, surviving Bonferroni correction. (C) Serum NfL had high accuracy to distinguish among patients with manifest SCA2, those with preSCA2, and controls and between individuals with SCA2 and controls.