Correction to: Mol Syst Biol (2021) 17: e10179. DOI: 10.15252/msb.202010179 | Published online 30 March 2021
In this study, the authors stated: “To our knowledge, this is the first identification of single‐protein genetic sensors with band‐stop dose‐response curves”. After the publication of the Tack et al (2021) study and while preparing a related manuscript, they found some early publications describing LacI variants with “band‐stop” dose–response curves. In those earlier papers (from the 1960s and 1970s), what Tack et al (2021) refer to as band‐stop variants were denoted as the “reversed” or “i r” phenotype. While preparing the Tack et al (2021) study, they mistakenly thought that “reversed” was synonymous with “inverted” (a term also used in other recent studies). As such, despite being aware that “reversed” variants had been observed before, they did not realize that they were similar to what they refer to as “band‐stop” variants.
The earlier publications describing reversed (i.e., band‐stop) LacI variants include the following: a study of temperature‐sensitive variants (Sadler & Novick, 1965); studies of the LacI X86 mutant, a reversed variant that is not temperature‐sensitive (Chamness & Willson, 1970; Jobe & Bourgeois, 1972); studies of variants that bind to DNA operator more tightly than the wild‐type (Betz & Sadler, 1976; Schmitz et al, 1978); and studies of a large number of mutations, including X86 and other reversed variants (Miller & Schmeissner, 1979; Miller et al, 1979).
Besides the sentence quoted above, this mistake does not impact the findings of the study. The authors apologize for this error.
Mol Syst Biol. (2021) 17: e10847
References
- Betz JL, Sadler JR (1976) Tight‐binding repressors of lactose operon. J Mol Biol 105: 293–319 [DOI] [PubMed] [Google Scholar]
- Chamness GC, Willson CD (1970) An unusual lac repressor mutant. J Mol Biol 53: 561–565 [DOI] [PubMed] [Google Scholar]
- Jobe A, Bourgeois S (1972) Lac repressor‐operator interaction VII. Repressor with unique binding properties – X86 repressor. J Mol Biol 72: 139–152 [DOI] [PubMed] [Google Scholar]
- Miller JH, Coulondre C, Hofer M, Schmeissner U, Sommer H, Schmitz A, Lu P (1979) Genetic‐studies of the lac repressor IX. Generation of altered proteins by the suppression of nonsense mutations. J Mol Biol 131: 191–222 [DOI] [PubMed] [Google Scholar]
- Miller JH, Schmeissner U (1979) Genetic‐studies of the Lac repressor X. Analysis of missense mutations in the LacI gene. J Mol Biol 131: 223–248 [DOI] [PubMed] [Google Scholar]
- Sadler JR, Novick A (1965) Properties of repressor and kinetics of its action. J Mol Biol 12: 305–327 [DOI] [PubMed] [Google Scholar]
- Schmitz A, Coulondre C, Miller JH (1978) Genetic studies of Lac repressor V. Repressors which bind operator more tightly generated by suppression and reversion of nonsense mutations. J Mol Biol 123: 431–454 [DOI] [PubMed] [Google Scholar]
- Tack DS, Tonner PD, Pressman A, Olson ND, Levy SF, Romantseva EF, Alperovich N, Vasilyeva O, Ross D (2021) The genotype‐phenotype landscape of an allosteric protein. Mol Syst Biol 17: 10.15252/msb.202010179 [DOI] [PMC free article] [PubMed] [Google Scholar]