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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Pain. 2022 Mar 1;163(3):508–517. doi: 10.1097/j.pain.0000000000002376

FIGURE 7. Effects of microglial depletion on OIH expression induced by different dosaging paradigms of morphine administration.

FIGURE 7.

PLX5622 treatment did not change the temporal expression of mechanical OIH induced by either constant or escalating dosaging of morphine. Constant morphine dosaging (20mg/kg, i.p./day for 7 days) or escalating dosaging (from 20, 25, 30, 35, 40, 45, 50mg/kg/day) were used to induce OIH in C57BL/6 male mice. PLX5622 treatment started at 5 days before the first dose of morphine. (N=6 mice/group).