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. Author manuscript; available in PMC: 2021 Dec 17.
Published in final edited form as: IUPHAR BPS Guide Pharm CITE. 2021 Sep 2;2021(3):10.2218/gtopdb/f51/2021.3. doi: 10.2218/gtopdb/f51/2021.3

Orexin receptors in GtoPdb v.2021.3

Paul Coleman 1, Luis de Lecea 2, Anthony Gotter 1, Jim Hagan 3, Daniel Hoyer 4, Thomas Kilduff 5, Jyrki P Kukkonen 6, Rod Porter 3, John Renger 1, Jerome M Siegel 7, Gregor Sutcliffe 2, Neil Upton 3, Christopher J Winrow 1
PMCID: PMC8682808  NIHMSID: NIHMS1759961  PMID: 34927075

Abstract

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [42]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [109]. Currently the only orexin receptor ligands in clinical use are suvorexant and lemborexant, which are used as hypnotics. Orexin receptor crystal structures have been solved [134, 133, 54, 117, 46].

Contents

This is a citation summary for Orexin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. For further details see [19].

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Footnotes

References

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