Dear Editor
we would like to share ideas on the publication “Venous sinus thrombosis after the second jab of an mRNA-based SARS-CoV-2 vaccine”.1 Finsterer and Nics concluded that “This case shows that also the second dose of the Pfizer vaccine can be followed by a VST. Currently, there are more arguments in favour of a causal relation between the vaccination and the VST than against it”.1 Thormbohemostasis after COVID-19 vaccination si an important problem. The present case might or might not be a case of vaccine complication. Regarding mRNA vaccine, it can also cause the thrombosis. In a previous study, it is apparently that there will be a significant increase of blood viscosity after the second dose of COVID-19 vaccine regardless of vaccine type.2 This case might be co-incidence. Since there is no data on background neurovascular status of the patient, it is difficult to have a final conclusion on causal relationship. In a case with underlying neurological problem, there is an increased change of hyperviscosity after vaccination and it might be associated with thrombosis.3 Additionally, other underlying illness of patient can also be the cause of thrombosis, which is considered a coincidence.4
Funding
None.
Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.
Ethical statement and patient’s consent
Informed consent was waived because of the retrospective nature of this study.
Consent for publication
All the authors have consented for publication of this manuscript.
References
- 1.Finsterer J., Nics S. Venous sinus thrombosis after the second jab of an mRNA-based SARS-CoV-2 vaccine. Brain Hemorrhages. 2021 Dec 8 doi: 10.1016/j.hest.2021.12.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Joob B., Wiwanitkit V. Expected Viscosity After COVID-19 Vaccination, Hyperviscosity and Previous COVID-19. Clin Appl Thromb Hemost. 2021 Jan-Dec;27 doi: 10.1177/10760296211020833. 10760296211020833. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Mungmunpuntipantip R., Wiwanitkit V. Safety Interval From Increased Viscosity After COVID-19 Vaccination Among Persons With Cerebrovascular Problems. Clin Appl Thromb Hemost. 2021 Jan-Dec;27 doi: 10.1177/10760296211039015. 10760296211039015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Mungmunpuntipantip R., Wiwanitkit V. Thrombosis After Adenovirus-Vectored COVID-19 Vaccination: A Concern on Underlying Illness. Clin Appl Thromb Hemost. 2021 Jan-Dec;27 doi: 10.1177/10760296211060446. 10760296211060446. [DOI] [PMC free article] [PubMed] [Google Scholar]