REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Plasma samples from COVID-19 hospitalised patients (cohort 1)	Manchester hospitals under the framework of the Manchester Allergy, Respiratory and Thoracic Surgery (ManARTS) and the Northern Care Alliance Research Collection (NCARC)	ManARTS Biobank (study no M2020-88, ethics: 15/NW/0409); NCARC tissue biobank (study no. NCA-009; ethics 18/WA/0368).
Leftover hospital blood samples from hospitalised COVID-19 patients (cohort 2)	York District Hospital, York and Scarborough NHS Trust	REC reference 19/YH/0394 with approved SA002 amendment of IRAS project 269597
Critical commercial assays
LEGENDplex™ HU Th Cytokine Panel (12-plex) w/ VbP V02	BioLegend	Cat #741028
LEGENDplex Human Proinflammatory chemokine Panel 1	BioLegend	Cat #741081
LEGENDplex Human CCL5 1-plex	BioLegend	Cat #741083
GM-CSF ABTS ELISA kit	Peprotech
Norgen Plasma/Serum RNA Purification Mini kit	Norgen	Cat #55000
miRNA Taqman assays	Thermo Fischer	Cat #4427975
Taqman MicroRNA Reverse Transcription Kit	Thermo Fischer	Cat #4366596
Taqman Universal PCR Master Mix	Thermo Fischer	Cat #4305719
Nanostring human v3 miRNA for 827 human miRNAs	Nanostring	CSO-MIR3-12
Deposited data
Nanostring miRNA data	GEO	GSE189610
Software and algorithms
R statistical programming language	The R project	https://r-project.org
Prism	GraphPad	https://graphpad.com
Other
StepOnePlus Real Time PCR System	Thermofisher	Cat #4376600
nCounter® FLEX Analysis System – nCounter Prepstation	Nanostring Inc	NA
nCounter® FLEX Analysis System – nCounter Digital Analyser	Nanostring Inc	NA