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Comparison of library-free peptide detection methods for DIA data
| Spectrum-centric | Peptide-centric | In silico library | ||
|---|---|---|---|---|
|
|
DIAmeter |
DIA-Umpire |
PECAN |
Prosit+EncyclopeDIA |
| Supports wide isolation windows | ✓ | ✓ | ||
| Detects PTMs | ✓ | ✓ | ✓ | |
| Instrument independent | ✓ | ✓ | ||
| Detects peptides with undetectable precursor | ✓ | ✓ | ✓ | |
