Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 1;12(1):362–378. doi: 10.7150/thno.65597

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

FUS-induced BBB disruption verified by contrast-enhanced T₁-weighted MRI scans. (A) Hardware setup for MRI-guided sonobiopsy in mice. The FUS transducer was coupled with the mouse head using ultrasound gel and a bladder filled with degassed water. (B) Contrast-enhanced (CE) T₁-weighted MRI scans were acquired before FUS to quantify the tumor volume (blue area). Post-FUS MRI scans confirmed FUS-induced BBB disruption (orange area) as an increase in CE volume. (C) FUS significantly increased the CE volume (n = 19, p = 0.0000038; ^****p < 0.0001; paired samples Wilcoxon signed rank test) from 24.59 ± 13.21 mm³ to 46.09 ± 20.44 mm³. Black bars indicate mean in C.