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. 2022 Jan 1;12(1):362–378. doi: 10.7150/thno.65597

Figure 5.

Figure 5

Sonobiopsy increased the sensitivity of EGFRvIII and TERT C228T mutation detections in pig plasma by ddPCR. (A) 1D amplitude plots for EGFRvIII detection in plasma for each subject. (B) Sonobiopsy significantly increased plasma levels of EGFRvIII ctDNA (n = 7; p = 0.016; *p < 0.05; paired samples Wilcoxon signed rank test) from 13.69 ± 28.62 copies/mL to 3697.54 ± 3780.61 copies/mL. (C) 1D amplitude plots for TERT C228T detection in plasma for each subject. (D) Sonobiopsy significantly increased the plasma levels of TERT C228T ctDNA (n = 10; p = 0.022; *p < 0.05; paired samples Wilcoxon signed rank test) from 13.07 ± 23.08 copies/mL to 112.25 ± 150.75 copies/mL. (E) With ddPCR, sonobiopsy is more sensitive than blood LBx with a detection rate of 100% for EGFRvIII and 71.43% for TERT C228T compared with 28.57% and 42.86% for blood LBx, respectively. ND: not detected. Black bars indicate mean in B and D.