Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection

Correction to: Virologica Sinica 10.1007/s12250-021-00445-0

In the original version of this article, one image in Fig. 4 was accidently duplicated during figure layout and the dilution rate was mislabeled. The correct Fig. 4 and its legend are given below:

Fig. 4.

PPP is indispensable for JEV replication. A Heatmap analysis of significantly changed metabolites associated with purine and pyrimidine metabolism. B–G Intervention of PPP by 6-AN significantly inhibits JEV replication in Neuro2a cell line and mouse primary neurons at 24 hpi. JEV mRNA levels in JEV-infected Neuro2a cells (B) and mouse primary neurons (E) treated with 6-AN at 24 hpi were detected by qPCR analysis. The level of mRNA expression was normalized with β-actin. The expression levels of viral protein NS3 in JEV-infected Neuro2a cells (C) and mouse primary neurons (F) were detected by Western blot analysis. Plaque formation assay shows the reduction of plaque generation in JEV-infected Neuro2a cells (D) and mouse primary neurons (G). 10³, 10⁴, 10⁵ and 10⁶ represented the dilution rate. H qPCR analysis of JEV mRNA level shows that anaplerosis of D-ribose 5-phosphate under 6-AN treatment condition could partially restore the viral replication. *P < 0.05; **P < 0.01