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. 2022 Jan 1;12(2):929–943. doi: 10.7150/thno.66148

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Suppression of the tumorigenic behaviors of EO771 mammary tumor cells by MC3T3 osteoblasts with the overexpression of Lrp5 and β-catenin, and the treatment of BML284. Ob = MC3T3 osteoblasts, Hob = human osteoblasts, CM = osteoblast-derived conditioned medium, siL5 = Lrp5 siRNA, and βcat = β-catenin overexpression. The single and double asterisks indicate p < 0.05 and 0.01, respectively. (A-C) Reduction in the scratch-based motility, EdU-based proliferation, and transwell invasion of EO771 mammary tumor cells by Lrp5 CM. (D-F) Elevation in the scratch-based motility, EdU-based proliferation, and transwell invasion by Lrp5-silenced CM. (G-H) Reduction in the EdU-based proliferation and transwell invasion of EO771 mammary tumor cells by β-catenin Ob CM. (I-J) Reduction in the MTT-based proliferation and scratch-based motility of MDA-MB-231 breast cancer cells by Lrp5-overexpressing Hob CM.