Table 3.
Antioxidants in the treatment of age-unrelated ART failure.
| Antioxidants | Type of Study | Outcome | References |
|---|---|---|---|
| Vitamin C | Prospective cohort | No effect on ART outcomes | [55] |
| RCT | No improvement of IR and CPR in ART | [56] | |
| Vitamin E | Observational, non-interventional | Positive correlation of serum and FF levels with oocyte maturity and embryo quality | [57] |
| Coenzyme Q10 | RCT | Less aneuploidy in IVF embryos | [58] |
| RCT | Increased FR No effect on CPR and LBR |
[59] | |
| Resveratrol | Retrospective | Decreased CPR | [62] |
| Increased MR | [63] | ||
| Melatonin | Prospective cohort | Fewer degenerated oocytes | [64] |
| Prospective cohort RCT |
Increased FR Improved oocyte and embryo quality |
[65] [68] |
Abbreviations: ART: assisted reproduction technology; IR: implantation rate; CPR: cumulative pregnancy rate; IVF: in vitro fertilization; FF: follicular fluid; MR: miscarriage rate.