Table 1.
Demographic, histological, and clinical characteristics of patients and IL-17A levels.
| Characteristics | All | IL-17A Low (≤10.0) | IL-17A Medium (10.1–17.9) | IL-17A High (≥18.0) | p Value b |
|---|---|---|---|---|---|
| N = 26 | (n = 9) | (n = 9) | (n = 8) | ||
| N a (%) | N a (%) | N a (%) | N a (%) | ||
| Sex | |||||
| Males | 12 (46.1) | 1 (11.1) | 5 (55.6) | 6 (75.0) | |
| Females | 14 (53.9) | 8 (88.9) | 4 (44.4) | 2 (25.0) | 0.026 |
| Age, years | |||||
| median (IQR) | 61 (49–73) | 55 (46–81) | 60 (41–68) | 65 (54–72) | 0.576 c |
| <60 | 12 (46.1) | 5 (55.6) | 4 (44.4) | 3 (37.5) | |
| ≥60 | 14 (53.9) | 4 (44.4) | 5 (55.6) | 5 (62.5) | 0.885 |
| Breslow thickness, mm | |||||
| median (IQR) | 5.0 (3.3–8.0) | 7.0 (5.0–9.0) | 5.0 (4.0–5.0) | 4.5 (2.9–6.3) | 0.402 c |
| ≤4.00 | 9 (34.6) | 2 (22.2) | 3 (33.3) | 4 (50.0) | |
| ≥4.01 | 17 (65.4) | 7 (77.8) | 6 (66.7) | 4 (50.0) | 0.521 |
| Anatomic site | |||||
| Head/neck | 3 (11.5) | 2 (22.2) | 1 (11.1) | 0 (-) | |
| Trunk | 10 (38.5) | 3 (33.3) | 4 (44.4) | 3 (37.5) | |
| Limbs | 13 (50.0) | 4 (44.4) | 4 (44.4) | 5 (62.5) | 0.894 |
| Histological type | |||||
| superficial spreading | 9 (36.0) | 2 (22.2) | 5 (62.5) | 2 (25.0) | |
| nodular | 16 (64.0) | 7 (77.8) | 3 (37.5) | 6 (75.0) | 0.264 |
| Mitotic rate | |||||
| low (<1 mitosis/mm2) | 4 (25.0) | 2 (28.6) | 1 (20.0) | 1 (25.0) | |
| high (≥1 mitoses/mm2) | 12 (75.0) | 5 (71.4) | 4 (80.0) | 3 (75.0) | 1 |
| Presence of ulceration | |||||
| no | 17 (65.4) | 6 (66.7) | 4 (44.4) | 7 (87.5) | |
| yes | 9 (34.6) | 3 (33.3) | 5 (55.6) | 1 (12.5) | 0.264 |
| Cell type | |||||
| epithelioid | 20 (80.0) | 8 (88.9) | 6 (75.0) | 6 (75.0) | |
| other | 5 (20.0) | 1 (11.1) | 2 (25.0) | 2 (25.0) | 0.696 |
| TILs | |||||
| scantly | 10 (76.9) | 4 (100.0) | 2 (50.0) | 4 (80.0) | |
| moderate | 3 (23.1) | 0 (-) | 2 (50.0) | 1 (20.0) | |
| marked | 0 (-) | 0 (-) | 0 (-) | 0 (-) | 0.441 |
| Sentinel lymph node status | |||||
| negative | 7 (70.0) | 2 (50.0) | 2 (66.7) | 3 (100.0) | |
| positive | 3 (30.0) | 2 (50.0) | 1 (33.3) | 0 (-) | 0.700 |
IQR, Interquartile Range; a totals may vary because of missing value; b Fisher’s exact test; c Kruskal–Wallis test.