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Schema of putative regulation mechanism of HIF-1α by SIRT2. The effects of SIRT2 on HIF-1α function remain unclear. Some studies support SIRT2 as an HIF-1α stabilizer, whereas others have shown that SIRT2 leads to degradation of HIF-1α via deacetylation at K709. HIF, hypoxia-inducible factor. K, lysine.
