Table 3.
TSLP and skin. Results include psoriasis and atopic dermatitis. The results are ordered by year and a quick recap was produced by author’s name, disease, specimens used and results.
| Author | Disease Studied | Species Examined | Year | Results |
|---|---|---|---|---|
| Schaper et al. [34] | Pso | Colture cells | 2016 | Pso patients present high levels of inflammation-related isoform of TSLP |
| Segawa et al. [35] | Pso | Colture cells | 2017 | EGFR is transactivated via TSLP by TNF-alpha |
| Desmet et al. [36] | Pso | Colture cells | 2018 | miRNA against TSLP topically used decreases the release of TSLP |
| Tashiro et al. [37] | Pso | Colture cells | 2019 | TSLP presents reduced levels in hypoxic conditions |
| Gago-Lopez et al. [38] | Pso | Animals | 2019 | Antibodies anti-TSLP lead to a positive response in epidermal thickening and vascularization |
| Chen et al. [39] | Pso | Humans | 2021 | Early onset patients have high levels of Th2 cells and TSLP |
| Bogaczewicz et al. [40] | AD | Humans | 2015 | UV-A therapy does not lower TSLP serum levels |
| Lee et al. [41] | AD | Colture cells | 2016 | TSLP acts as a downregulator of the AMPs via the JAK/STAT3 pathway |
| Wallmeyer et al. [42] | AD | Animals | 2017 | TSLP acts upon T lymphocytes switching the immune response from Th1/Th17 to Th2/Th22 without the aid of dendrocytes |
| Chang et al. [43] | AD | Humans | 2017 | Patients with mutation of TSLP rs1898671 homozygotes are less likely to use calcineurin inhibitors instead of steroids |
| Uysal et al. [44] | AD | Humans | 2017 | Higher levels of TSLP in the blood correlate to severity of clinical manifestations |
| Kumagai et al. [45] | AD | Colture cells | 2017 | ΔNp63 is a positive feedback stimulus in the production of TSLP |
| Gourru-Lesimple et al. [46] | AD | Colture cells | 2017 | MV modulate the expression of TSLP |
| Mizuno et al. [47] | AD | Colture cells | 2017 | Pentanoic acid is a potent inducer of TSLP |
| Guo et al. [48] | AD | Animals | 2018 | Metallothionein knock down mice show higher levels of TSLP |
| Yoou et al. [49] | AD | Animals | 2018 | Bamboo salt lowers levels of TSLP by stimulating IL-32 on monocites |
| Kim et al. [50] | AD | Animals | 2018 | Kestose oral administration suppresses TSLP expression |
| Herro et al. [51] | AD | Animals | 2018 | Tumor necrosis factor (TNF) superfamily protein LIGHT (homologous to lymphotoxin), exhibits inducible expression and competes with HSV glycoprotein D for binding to HVEM, (a receptor expressed on T lymphocytes) upregulates the TSLP production |
| Barr et al. [52] | AD | Animals | 2018 | PZ-235 treatment reduces thickening of AD lesions |
| Lou et al. [53] | AD | Humans | 2019 | rs1898671 variant of TSLP is linked to AD developing in African American children and related to food and drug allergy |
| Moon et al. [54] | AD | Animals | 2019 | Anthraquinone treatment reduces TSLP levels |
| Ko et al. [55] | AD | Animals | 2019 | Ginsenoside Rh2 damps the effects of TSLP by affecting NF-kB |
| Wang et al. [56] | AD | Animals | 2019 | Block of miR-155-5p leads to higher production of filaggrin, lesser production of TSLP and IL-33 |
| Noh et al. [57] | AD | Humans | 2019 | ZAG regulates TSLP secretion |
| Gu et al. [58] | AD | Colture cells | 2020 | Bland topical treatments turn down the expression of TSLP |
| Kitajima et al. [59] | AD | Animals | 2020 | Blockade of the receptor of TSLP (TSLPR) in CD4+ lymphocytes interrupts the chronic phase of inflammation |
| Lyubchenko et al. [60] | AD | Humans | 2020 | TSLP isolated from AD patients’ skin |