Table 3.
Summary of CD44 interactomes and their effects on cancer progression.
| Effect | Cancer Type | Reference | |
|---|---|---|---|
| Hyaluronan (HA) | Stemness (spheroid and clone formation, self-renewal), cell growth, poor differentiation, chemoresistance | Head and neck CSCs | [134] |
| Hyaluronan (HA) | Cell survival, migration, poor prognosis | Pancreatic cancer | [135] |
| Hyaluronan (HA) | Cell motility, invasion, tumour progression | Pleural mesothelioma | [136] |
| Hyaluronan (HA) | Cell proliferation, poor survival | Melanoma | [137,138] |
| Hyaluronan (HA) | Cancer cells rolling, metastasis | Liver cancer | [139] |
| Hyaluronan (HA) | Cell proliferation | Acute myeloid leukaemia | [140] |
| Osteopontin (OPN) | Metastasis | Bladder cancer | [153] |
| Osteopontin (OPN) | Tumour growth, tumour recurrence, cell survival, metastasis, CSCs phenotype maintenance | Hepatocellular carcinoma | [154] |
| Osteopontin (OPN) | Invasion | Pancreatic cancer | [136,156] |
| Osteopontin (OPN) | Tumour progression and recurrence | Ovarian cancer | [157] |
| Osteopontin (OPN) | Migration | Breast cancer | [158] |
| Osteopontin (OPN) | Radio-resistance | Colorectal carcinoma | [159] |
| Osteopontin (OPN) | Tumour immune evasion | Colon carcinoma | [160] |
| Osteopontin (OPN) | Cell proliferation | Lung cancer | [161] |
| Osteopontin (OPN) | Aggressive growth, stemness, radio-resistance | Glioma CSCs | [80] |
| Osteopontin (OPN) | Tumour progression, metastasis | Gastric cancer | [162] |
| Matrix metalloproteinase14 (MMP-14) | Migration | Pancreatic cancer, breast cancer, osteosarcoma | [164] |
| Matrix metalloproteinase14 (MMP-14) | Invasion, migration | Colon carcinoma | [165] |
| Matrix metalloproteinase 14 (MMP-14) | Poor prognosis | Ovarian cancer | [166] |
| Matrix metalloproteinase 14 (MMP-14) | Poor prognosis, invasion | Breast cancer | [167] |
| Matrix metalloproteinase 9 (MMP-9) | Cell adhesion, invasion, migration | Glioblastoma | [171] |
| Matrix metalloproteinase 9 (MMP-9) | Invasion, metastasis stage | Renal carcinoma | [175] |
| Matrix metalloproteinase 9 (MMP-9) | Invasion, migration, sphere formation | Prostate cancer | [177] |
| Matrix metalloproteinase 2 (MMP-2) | Lymph node metastasis, histopathological grade, TNM stage, poor prognosis | Non-small cell lung cancer | [173] |
| Matrix metalloproteinase 2,9 (MMP-2), (MMP-9) | Invasion | Breast cancer | [174] |