Figure 4.

Schematic of PROTACs and molecular glue mechanism. (A) PROTAC acts as a medium for inducing E3 ligases to successfully “hold hands” with the target protein, thus forming a stable E3 ligase–PROTAC–target protein ternary complex to induce ubiquitination and proteasome degradation of the target protein. (B) Molecular glue, similar to “double-sided glue,” degrades the target protein by inducing or stabilizing the interaction between E3 ligases and the target protein. Some of the graphics in this figure was created using ScienceSlides software 2016 edition (VisiScience Inc., NC, USA).