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. 2021 Dec 12;11(12):1868. doi: 10.3390/biom11121868

Figure 1.

Figure 1

WRNexoΔ females are not sensitive to exogenous oxidative stress regardless of age. (A) Representative Kaplan–Meyer survival curves for adult survival following hydrogen peroxide exposure. (Mantel–Cox log-rank between w1118 and WRNexoΔ controls: * p < 0.05, *** p < 0.001; Mantel–Cox log-rank between H2O2-treated w1118 and WRNexoΔ: ## p < 0.01, ### p < 0.001, n = 38–130). (B) Summary data depicting mean lifespan of flies exposed to H2O2. (2-way ANOVA, n = 2–3 independent experimental replicates/per condition ± SEM). (C) Normalized lifespans following 5% hydrogen peroxide showed resistance of younger, but not aged WRNexoΔ females (2-way ANOVA, * p < 0.05, *** p < 0.001, ±SD, n = 128–259 females from 2 to 3 independent experimental replicates). (D) Crude protein extracts from young WRNexoΔ adults had the greatest neutralization effect on the stable free radical DPPH demonstrating higher antioxidant activity (paired t-test, * p < 0.05, ±SEM).