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. 2021 Dec 20;10(12):3589. doi: 10.3390/cells10123589

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cytokines IL-10 and IL-6, and IL-18 are decreased in patients with rs1042058 TPL2 variant in CD and UC, respectively. Intestinal biopsies from CD and UC patients with or without rs1042058 TPL2 variant were analyzed for mRNA expression of inflammatory cytokines. Graphs demonstrate mRNA levels of (A) TPL2 in CD patients stratified by the presence of the rs1042058 TPL2 variant, (B) IL-10 in DC patients, (C) IL-6 in CD patients, and (D) IL-18 mRNA expression in UC patients shows a significant decrease when carrying the rs1042058 TPL2 variant. Error bars represent means ± SD. * = p < 0.05.