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. 2021 Dec 10;12:746734. doi: 10.3389/fpsyt.2021.746734

Pareidolia in Schizophrenia and Bipolar Disorder

Eid G Abo Hamza 1,2,*, Szabolcs Kéri 3,4,5, Katalin Csigó 3, Dalia Bedewy 1,2, Ahmed A Moustafa 6,7
PMCID: PMC8702957  PMID: 34955913

Abstract

While there are many studies on pareidolia in healthy individuals and patients with schizophrenia, to our knowledge, there are no prior studies on pareidolia in patients with bipolar disorder. Accordingly, in this study, we, for the first time, measured pareidolia in patients with bipolar disorder (N = 50), and compared that to patients with schizophrenia (N = 50) and healthy controls (N = 50). We have used (a) the scene test, which consists of 10 blurred images of natural scenes that was previously found to produce illusory face responses and (b) the noise test which had 32 black and white images consisting of visual noise and 8 images depicting human faces; participants indicated whether a face was present on these images and to point to the location where they saw the face. Illusory responses were defined as answers when observers falsely identified objects that were not on the images in the scene task (maximum illusory score: 10), and the number of noise images in which they reported the presence of a face (maximum illusory score: 32). Further, we also calculated the total pareidolia score for each task (the sum number of images with illusory responses in the scene and noise tests). The responses were scored by two independent raters with an excellent congruence (kappa > 0.9). Our results show that schizophrenia patients scored higher on pareidolia measures than both healthy controls and patients with bipolar disorder. Our findings are agreement with prior findings on more impaired cognitive processes in schizophrenia than in bipolar patients.

Keywords: psychosis, visual illusion, pareidolia, bipolar disorder, schizophrenia

Introduction

Schizophrenia (SCZ) is a psychiatric disorder characterized by positive and negative symptoms (1). Positive symptoms involve delusions and hallucinations, while negative symptoms include avolition and diminished emotional expression. Bipolar disorder (BPD) is a mood disorder characterized by alternating states of depression and mania or hypomania (1). As we discuss below, both disorders show both similar and dissimilar kinds of perceptual, cognitive, and neural patterns.

Studies have shown that patients with bipolar disorder and schizophrenia show both similar and dissimilar neural abnormalities [for discussion on this point, see (2–4)]. For example, one study reported that genes underlying dopamine function in the prefrontal cortex are similarly implicated in both schizophrenia and bipolar disorder (5). Parker et al. (6) found that the neural similarities in both schizophrenia and bipolar disorder depends on severity of psychosis in bipolar disorder. Unlike bipolar patients without psychosis, bipolar disorder patients with psychosis tends to show similar EEG responses (particularly P50) to schizophrenia. Given that several studies show that patients with bipolar disorder show milder forms of cognitive dysfunction in comparison to patients with schizophrenia (7), it is expected that schizophrenia patients will show more widespread and severe neural damage compared to patients with bipolar disorder. Confirming this, it has been reported that while patients with bipolar disorder and schizophrenia show both prefrontal and striatal damage (8–10), these abnormalities are pronounced in patients with schizophrenia than in patients with bipolar disorder (11). In sum, neural studies have shown that patients with bipolar disorder show milder neural abnormalties than patients with schizophrenia and that severity of psychosis in bipolar disorder is associated with more accentuated neural damage.

Perception, Visual Illusion, and Pareidolia

Our perception of the world is not solely determined by the input to our senses, but is strongly influenced by our prior experience with the world. A visual percept is inferred from often fragmentary and incomplete visual signals from the eyes through a process of unconscious inference (12). For example, a face emerging from the shadows, which is barely visible, can be recognized despite only a small patch of light being received by the retina. The rest of the face is inferred based on prior knowledge, expectations, and our beliefs about faces. Illusory face detection is common in the human population (e.g., detection rates as high as 41%) (13); however, research suggests substantial individual variation (14).

Several studies suggest that illusion can result from deficits in top-down processing, that is, existing cognitive and perceptual biases (15–19) or an imbalance between top-down internal factors (e.g., perceptual expectations, prior knowledge, and mental imagery) and bottom-up external sensory input (15, 20). Moreover, sensory isolation can induce the same effect as a perceptual bias toward prior expectations that leads to visual illusion (21, 22).

Auditory illusion, often known as auditory misperception or hallucinations, is defined as perceiving sounds that do not exist in the presented stimuli, is common in schizophrenia. Auditory illusion has been reported using several experimental paradigms (23–25). Thus, a better understanding of the underlying cause may help treat such symptoms and prevent such outcomes. Typically, illusion in schizophrenia patients include people, faces, animals, objects with frightening content (26–28). Like schizophrenia, patients with bipolar disorder also show visual illusion (29, 30). However, compared to schizophrenia, there are fewer studies on visual hallucinations and illusions in bipolar disorder (29, 31). Prior studies have found that patients with bipolar disorder are similar to healthy controls in terms of experiencing illusion. For example, Keane et al. (32) found that patients with bipolar disorders and healthy controls show normal depth inversion illusions, while patients with schizophrenia show reduced depth inversion illusions. It is important to note that unlike other forms of illusions, experiencing depth inversion illusion is considered normal and common, and not experiencing this form of illusion is associated with neural abnormalities in the parietal-frontal network (33). However, some studies found that both patients with bipolar disorder and schizophrenia show similar performance in the Mueller-Lyer illusion task (30, 34).

Pareidolia is the perception of faces in ambiguous visual stimuli, such as clouds, rock formations, or flocks of birds, and is thus a type of visual illusion (35). Pareidolia occurs when an indistinct and often randomly formed stimulus is interpreted as being definite and meaningful. This is something that many individuals have experienced, whether exercising their imagination as a cloud-gazing child, or seeing images in a textured ceiling during the last few waking moments of the day.

Several studies show that healthy “normal” people report pareidolic experiences. Uchiyama et al. (36) found that pareidolia is related to impaired visual and perceptual processes. There have been several studies investigated personality traits and individual differences in relation to pareidolia (37). It was reported that pareidolia is high in religious individuals (38) and individuals high in schizotypy (39). Other studies found that mood states and feeling lonely may increase the occurrence of pareidolia (40). Pareidolic experiences are commonly reported during the use of hallucinogens such as Lysergic Acid Diethylamide (LSD) in healthy individuals [for discusssion see, (41)]. One recent ERP study has investigated the occurrence of pareidolia in healthy individuals, showing that some EEG components can differentiate faces from face pareidolia (42). In this study, N170 was larger for faces than face pareidolia, but VPP was larger for face pareidolia than for faces. Using fMRI, Wardle et al. (43) found that face pareidolia is associated with the activation of fusiform area.

In addition, there have been few studies investigating pareidolia in patient populations including autism (44), patients with migraine (45), schizophrenia (46), Lewy Bodies Dementia (36), and Parkinson's disease (47). To our knowledge, there are only two study investigating pareidolia in schizophrenia (46, 48), and no study has investigated pareidolia in bipolar disorder.

The Current Study

The current study has, for the first time, investigated and compared pareidolia measures in both schizophrenia and bipolar disorder patients, using tasks that were not previously used with these patient populations. In addition, we have also used several other clinical measures including the Structured Interview for Assessing Perceptual Anomalies (SIAPA) to measure both auditory and visual misperceptions.

Methods

Below, we describe the characteristics of our participants, pareidolia tests, and statistical analyses. The study was approved by the Hungarian Scientific and Research Committee of the Medical Research Council ethics board (Budapest, Hungary).

Participants

We enrolled 50 patients with schizophrenia, 50 patients with type I bipolar disorder with a history of psychotic symptoms, and 50 control volunteers without any history of psychiatric disorders. Participants were matched for age, sex, education, Intelligence Quotient (IQ), and general psychosocial functions (Table 1). The study was coordinated in the Nyíro Gyula National Institute of Psychiatry and Addictions and was approved by the Hungarian Scientific and Research Committee of the Medical Research Council ethics board (Budapest, Hungary). All participants gave written informed consents. The inclusion criteria are as follows: Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnosis of bipolar disorder or schizophrenia, ability and willingness to participate, age between 18 and 65 years, and lack of acute psychosis. All of our participants were outpatients. All patients lived in the community and were in clinical remission according to the Andreasen-criteria for schizophrenia (49) and to the Systematic Treatment Enhancement Program for Bipolar Disorder criteria for bipolar disorder (50).

Table 1.

Clinical and demographical characteristics of the participants.

Schizophrenia (SCZ) (n = 50) Bipolar disorder (BPD) (n = 50) Control participants (n = 50)
Age (years) 39.5 (8.4) 40.5 (7.9) 38.2 (8.5)
Sex (male/female) 32/18 32/18 32/18
Education (years) 11.8 (5.7) 11.7 (6.1) 12.0 (6.3)
IQ 98.4 (9.5) 100.5 (9.0) 101.7 (10.4)
Visual acuity (LogMAR) 0.17 (0.09) 0.19 (0.08) 0.17 (0.04)
Duration of Illness (years) 14.7 (8.3) 14.9 (9.1) –
WHODAS 2.0 21.3 (7.9) 20.4 (6.8) –
PANSS—P 15.7 (5.2) 16.8 (5.8) –
PANSS—N* 18.1 (4.8) 15.4 (5.1) –
PANSS—G 40.2 (10.1) 39.2 (12.1) –
HAM-D 10.3 (5.8) 10.9 (7.5) –
YMRS 4.5 (2.1) 4.0 (2.9) –
Chlorpromazine (CPZE)-equivalent antipsychotic dose (mg/day) 326.3 (179.4) 328.7 (215.5) –
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Data are mean (standard deviation) except the sex ratio. PANSS, Positive and Negative Syndrome Scale; HAM-D, Hamilton Rating Scale for Depression; YMRS, Young Mania Rating Scale; WHODAS 2.0, WHO Disability Assessment Schedule 2.0; *p < 0.05 (two-tailed t-test).

The exclusion criteria were as follows: neurological disorders and other general medical conditions affecting the central nervous system, evidence of head injury, electroconvulsive therapy, and psychoactive substance misuse confirmed by clinical history or by a urine test. In total, we have excluded only five patients with comorbid substance and alcohol misuse. Forty-seven patients with schizophrenia and 40 patients with bipolar disorder received either second-generation antipsychotic medications (amisulpride, olanzapine, quetiapine, and risperidone) or third-generation medication (e.g., aripiprazole) at the time of testing. In total, 32 schizophrenia patients, 34 bipolar disorder patients, and 30 controls regularly smoked tobacco. The chlorpromazine-equivalent doses, calculated by a standard method (51), are shown in Table 1. Twelve patients with schizophrenia and 45 patients with bipolar disorder also received mood stabilizers (lithium, valproate, or lamotrigine).

Pareidolia Tests and Clinical Measures

The pareidolia tests were based on the exact adoption of a previously published protocol (36, 52–54). The scene test consisted of 10 blurred images of natural scenes that frequently produced illusory face responses in a previous study (36, 53). The task goal was to point to and describe the objects on each image in as much detail as possible. The noise pareidolia test included 32 black and white images consisting of visual noise (spatial frequency: 1/f3) and 8 images depicting human faces. Participants were asked to respond whether a face was present on these images and to point to the location where they saw the face. The maximum exposure time was 60 s in the scene task and 30 s in the face task. Participants did not receive feedback on the appropriateness of their responses, and they were not informed that in the face task only noise was presented. Illusory responses were defined as answers when observers falsely identified objects that were not on the images in the scene task (maximum illusory score: 10), and the number of noise images in which they reported the presence of a face (maximum illusory score: 32). We also calculated the total pareidolia score for each task (the sum number of images with illusory responses in the scene and noise tests). The responses were scored by two independent raters with an excellent congruence (kappa > 0.9).

We used the following instruments for clinical evaluation: Structured Clinical Interview for DSM-5 Disorders—Clinician Version (SCID-5-CV) (55), Positive and Negative Syndrome Scale (PANSS) (56), Hamilton Rating Scale for Depression (HAM-D) (57), Young Mania Rating Scale (YMRS) (58), and the World Health Organization Disability Assessment Schedule (WHODAS 2.0) of the DSM-5 (1).

General intellectual and cognitive functions were measured with the Wechsler Adult Intelligence Scale-IV (WAIS-IV) (59). The DSM-5 structured clinical interview and the rating scales were administered by trained and supervised clinical psychologists or psychiatrists. Below, we provide a brief description of WHODAS 2.0, HAM-D, and PANSS scales.

WHODAS 2.0

This instrument enables assessment of health and disability in 6 domains (cognition, mobility, self-care, interacting with other people, life activities, participation in communities). The administration time is short (5 to 20 min), and WHODAS 2.0. is valid in clinical and general populations across cultures. The concept of WHODAS 2.0. is based on ICF (International Classification of Functioning, Disability and Health) principles.

HAM-D

We used the structured version of the 17-item HAM-D to assess the severity of depressive symptoms (e.g., depressed mood, feelings of guilt, suicide, and insomnia). Each item was rated on a 3-point (items 4–6, 12–14, 17) or 5-point Likert-scale (0—absent or no difficulty). A score in the range of 0–7 is normal. Patients scoring 20 or higher regularly require clinical attention.

PANSS

The patient is scored from 1 to 7 on 30 items classified according to positive, negative, and general symptoms. The positive symptom scale contains 7 items (minimum score = 7, maximum score = 49), such as delusions, conceptual disorganization, hallucinations, excitement, and grandiosity. The negative scale also consists of 7 items (e.g., blunted affect, emotional withdrawal, and poor rapport). Finally, the general psychopathology scale consists of 16 items (minimum score = 16, maximum score = 112) (e.g., somatic concerns, anxiety, guilt, and tension).

YMRS

The scale includes 11 items. Four items are graded on a 0 to 8 scale (irritability, speech, thought content, and disruptive or aggressive behavior), whereas seven items are graded on a 0 to 4 scale (e.g., elevated mood, increased motor activity, and sexual interest). A score of 20 or higher indicate severe mania.

Interview for the Assessment of Anomalous Visual and Auditory Experiences

We used the Structured Interview for Assessing Perceptual Anomalies (SIAPA) (60, 61). The SIAPA focuses on three aspects of anomalous perceptual experiences: sensory intensity (hypersensitivity), inundation or flooding, and selective attention to external stimuli on a scale of 0 (absent)−4 (pervasive). The interview begins with open-ended and then structured questions regarding subjective experiences in each sensory modality. For example, to assess hypersensitivity in the auditory modality, the following questions are presented: “Have you ever had the feeling or sensation that sounds were particularly loud? Or louder than usual? Or that your sense of hearing was particularly keen or sensitive? Or that your ears were picking up the slightest detail of sounds?” To evaluate inundation and flooding, participants are asked: “Have you ever had the experience or felt like you were being flooded or inundated by sounds? Or that you couldn't block out sounds? Or that it seemed as if your ears were picking up everything going on around you?” Finally, questions for selective attention are as follows: “Have you ever had the experience or felt like you couldn't pay attention to one sound, or a conversation, because of interference from other sounds, like background noise? Do you find that your attention is captured by irrelevant sounds, like traffic noises, even though they are of no interest to you?” (60). Similarly, in the visual modality, participants are asked whether lights seemed much brighter, colors were unusually vivid, the environment was bothersome, and whether they were overwhelmed by multiple objects in the scene and could not attend to one of many simultaneous visual inputs. We observed a good congruence between two independent raters (kappa > 0.7), and the internal consistency was good (Cronbach alpha > 0.8). The SIAPA scores correlated with objective psychophysical measures of sensory perception (61).

Statistical Analysis

The STATISTICA 13.1 (Tibco, Palo Alto) software package was used for data analysis. First, we tested data distribution and homogeneity of variance with Lilliefors and Levene's tests, respectively. Measures with normal distributions were entered into analyses of variance (ANOVAs) and two-tailed Student's t-tests. Dichotomous variables were analyzed with chi-square tests. The SIAPA and the pareidolia scores were not normally distributed (p < 0.01), and therefore we used Kruskal-Wallis analyses of variance (ANOVA) followed by multiple comparisons for mean ranks tests. Spearman's rank correlation coefficients were calculated between the pareidolia scores and the clinical measures. We used a receiver operating characteristic (ROC) analysis to test the sensitivity and specificity of the pareidolia test to differentiate schizophrenia from bipolar disorder or controls. The schizophrenia-control and schizophrenia- bipolar disorder differentiation was also investigated with discriminant function analyses. The level of statistical significance was set at alpha <0.05, corrected for multiple comparisons with the Bonferroni method.

Results

The Pareidolia Test

Kruskal-Wallis ANOVAs that were conducted on the number of illusory responses indicated a significant difference among patients with schizophrenia, bipolar disorder, and controls in the scene test [H (2) = 31.59, p < 0.001], in the noise test [H (2) = 29.68, p < 0.001], and in the total pareidolia score [H (2) = 33.30, p < 0.001]. Post-hoc tests indicated that patients with schizophrenia scored higher than controls and patients with bipolar disorder on all measures of pareidolia (p's < 0.01) (Figure 1). In contrast, we observed no significant between-group differences in the number of correctly identified faces in the noise task (p = 0.52; median: 8 in each group with a lower-upper quartile of 7–8).

Figure 1.

Figure 1

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Median scores in the scene and noise test, and in the total pareidolia measures. Error bars indicate range; boxes indicate 25–75% percentiles. **p < 0.001, schizophrenia patients outscoring controls and patients with bipolar disorder.

Pareidolia measures differentiated schizophrenia from controls with a sensitivity of 74% (scene test) and a specificity of 94% (total pareidolia score). In the schizophrenia—bipolar disorder differentiation, the highest sensitivity was 62% (total pareidolia score) and the highest specificity was 92% (noise test). The results from the ROC analysis are summarized in Table 2 and Figure 2.

Table 2.

Results from the ROC analysis.

SCZ—Control SCZ—BPD
Sensitivity Specificity AUC Cut-off Sensitivity Specificity AUC Cut-off
Scene test 0.74 0.72 0.78 2 0.58 0.86 0.77 3
Noise test 0.68 0.80 0.78 3 0.50 0.92 0.74 6
Pareidolia score 0.62 0.94 0.80 7 0.62 0.88 0.77 7 8
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Receiver operating characteristic (ROC) analysis using an optimal cut-off score set (Youden-method). SCZ, schizophrenia; BPD, bipolar disorder; AUC, area under the curve.

Figure 2.

Figure 2

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Receiver operating characteristic analysis for the pareidolia test to differentiate schizophrenia (SCZ) from controls (CONT) and schizophrenia from bipolar disorder (BPD).

Discriminant function analysis also indicated a significant difference between schizophrenia and controls in all tests (see Supplementary Table 1). Altogether, 76% of the cases were correctly classified by using the total pareidolia scores. In the schizophrenia- bipolar disorder discrimination, the most successful classification was also observed in the case of the total pareidolia scores (73% of correctly classified cases). In contrast, we observed no significant effects in the schizophrenia- bipolar disorder discrimination with a maximum of 57% of correctly classified cases (Supplementary Table 1).

Anomalous Perceptual Experiences (SIAPA) and Pareidolia

Kruskal-Wallis ANOVAs indicated a significant difference among patients with schizophrenia, bipolar disorder, and controls in the SIAPA visual modality [H (2) = 25.75, p < 0.001] and in the SIAPA auditory modality [H (2) = 22.25, p < 0.001]. As shown in Figure 3, patients with schizophrenia scored higher relative to the bipolar disorder and the control group in both visual and auditory modalities (p's < 0.01).

Figure 3.

Figure 3

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Median SIAPA (Structured Interview for Assessing Perceptual Anomalies) scores from the visual and auditory modalities. Error bars indicate range, boxes indicate 25–75% percentiles. **p < 0.001, schizophrenia patients outscoring controls and patients with bipolar disorder in both visual and auditory modalities.

Supplementary Table 2 depicts correlations between the pareidolia scores and clinical measures (including SIAPA, PANSS, and YMRS). In schizophrenia, there were significant positive relationships between the scene, noise, and total pareidolia scores and the SIAPA visual scores, which survived Bonferroni correction (rs > 0.6, p's < 0.001) (Figure 4). There were no significant correlations when the auditory SIAPA scores were included in the analysis, and the remaining correlations including PANSS and YMRS values did not reach the level of statistical significance (Supplementary Table 2).

Figure 4.

Figure 4

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Correlations between SIAPA (Structured Interview for Assessing Perceptual Anomalies) visual scores and (A) scence, (B) test, and (C) pareidolia test results. The correlation coefficients are shown in Supplementary Table 2.

Discussion

In the current study, we have measured pareidolia in patients with schizophrenia, patients with bipolar disorder, and healthy controls. To our knowledge, this is the first study to concurrently compare pareidolia measures in these populations. Our results show that schizophrenia patients show more illusory perception than patients with bipolar disorder and healthy controls. Similarly, our results also show that patients with schizophrenia scored higher than patients with bipolar disorder and healthy controls in both visual and auditory modalities of the Structured Interview for Assessing Perceptual Anomalies (SIAPA). Furthermore, we found a positive correlation between scene, noise, and pareidolia tests and visual scores of the SIAPA measures, but not with PANSS and YMRS. In addition, our study has also some novel findings that are not reported in prior studies. For example, we found that pareidolia measures successfully differentiated schizophrenia from health controls and also differentiated schizophrenia from bipolar disorder. However, pareidolia measures were not strong predictors of classifying healthy controls from bipolar disorder. In addition, patients with BPD and SCZ scored similarly and mildly on depression scales because they were in clinically stable conditions [for discussion on these points, see (62)]. The depression scores were low in both groups (mild-subthreshold level according to the NIHCE 2019 criteria) indicating no clinically significant major depressive episode in bipolar and schizophrenia patient. It is a major strength of the study because co-morbid depression is a serious confounding factor that may interfere with test results.

Our findings are in agreement with prior studies. A recent study has also reported face pareidolia in patients with schizophrenia using the Giuseppe Arcimboldo food-plate stimuli, which are stimuli made out of food but the whole stimulus is usually perceived as a face (48). However, our results are different from those of Mavrogiorgou et al. (46). Mavrogiorgou et al. (46) found that schizophrenia patients show less pareidolia symptoms than healthy individuals. The discrepancy in findings between these studies and ours can be related to the differences in demographical variables of healthy controls and schizophrenia patients in these studies. Specifically, our controls have average age of 38, while healthy controls in the Mavrogiorgou et al. (46) study have an average age of 46. The difference in age in schizophrenia patients in our study and that of Mavrogiorgou et al. (46) is less pronounced. Our schizophrenia patents have average age of 40, while healthy controls in the Mavrogiorgou et al. (46) study have an average age of 43. These differences in age, especially in age, may perhaps explain the discrepancy in findings. Furthermore, the discrepancy in findings between our study and that of Mavrogiorgou et al. (46) can be related to differences in stimuli, as the Mavrogiorgou et al. (46) used self report while we have used several novel cognitive pareidolia measures consisting of blurred images of natural scenes intended to produce illusory face responses.

There is also some evolutionary explanation of pareidolia. The ability to make sense of a stimulus based on noisy or ambiguous sensory data is suggested to be an adaptive function of the brain. The tendency to infer agency from sensory noise is thought to have evolved to serve an important function in predatory threat detection (63), but in daily life, can yield perceptual errors, such as mistaking an object as a face. However, another interpretation is that pareidolia is related to our increased cognitive fluidity and prosocial behavior (64). To test the plausibility of both views, future work should use and correlate surveys that measure predatory threat detection and prosocial behavior, along with measures of pareidolia.

There are debates in the field on whether schizophrenia and bipolar disorder fall on the same continuum or are vastly different disorders (65, 66). Existing data on this topic is conflicting. As mentioned in Introduction, some studies found that schizophrenia patients are more impaired than bipolar disorder patients on several cognitive measures (67, 68), which is in agreement with our results. However, other studies argue that such disorders fall on a continuum, and are not thus markedly different (69). In line with this view, some studies found that patients with schizophrenia and bipolar disorder patients with psychosis symptoms are similarly impaired on several cognitive measures, in comparison to healthy controls (70–74).

As mentioned above, illusion and pareidolia can results from top-down processing deficits (15–19). The question is, how can we explain our findings that schizophrenia patients show more pareidolia than healthy controls and patients with bipolar disorder? Here, we argue that this is possibly due to more damage in the prefrontal cortex in schizophrenia than in bipolar disorder patients, as discussed above (10, 75). In other words, it is possible that the more severe prefrontal damage in schizophrenia patients lead to an impaired top-down processing, and this in turn, lead to illusion and pareidolia. However, this mechanism should be investigated in future studies.

Limitations and Future Studies

Our study suffers from some limitations. For example, unlike prior studies, we did not include patients with bipolar disorder I and II (76, 77). Future work on pareidolia should include bipolar disorder patients with mania and hypomania. It is predicted that patients with bipolar disorder II may show reduced pareidolia than patients with bipolar disorder I. However, subgroups of schizophrenia with varying degrees of negative symptoms [i.e., deficit vs. non-deficit schizophrenia, (78, 79)] may not show any differences in measures of pareidolia. Further, future studies should also investigate pareidolia in individuals with schizotypal personality disorder as well as other patient groups with schizophrenia-related disorders, such as schizoaffective disorder. It is predicted that like schizophrenia, these patient groups may also show pareidolia. Other limitation of the study is we do not have enough information from participants regarding their racial/ethnic identification, and culture/geographic background, a measure of income, and socioeconomic status. In addition, another limitation is a larger number of bipolar disorders are on mood stabilizers than patients with schizophrenia. However, this is the case in almost all studies on schizophrenia and bipolar disorder, and it is often possible to match patient groups on their medication use.

Future studies should measure neural activations underlying the occurrence of pareidolia in patients with schizophrenia and bipolar disorder. Based on prior findings (80, 81), we predict that schizophrenia patients may show more fusiform area activation than patients with bipolar disorder during the performance of the scene test used in the task. Future work should investigate whether pareidolia is more common in psychotic bipolar disorder patients than in non-psychotic bipolar disorder patients. In addition, one study found that negative mood increases pareidolia in patients with Lewy body dementia (82). Future work should also investigate whether negative mood increase pareidolia in patients with schizophrenia and bipolar disorder. Future research should also investigate the impact of antipsychotics as well as other medications for the treatments of schizophrenia and bipolar disorder, such as lithium, on the occurrence of pareidolia.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Ethics Statement

The studies involving human participants were reviewed and approved by Hungarian Scientific and Research Committee of the Medical Research Council ethics board (Budapest, Hungary). The patients/participants provided their written informed consent to participate in this study.

Author Contributions

EA and DB developed the study concept. SK contributed to the study design. Testing and data collection were performed by SK and KC. SK and KC performed the data analysis and interpretation under the supervision of AM. AM drafted the paper. EA and AM provided critical revisions. All the authors acknowledged that they contributed equally in the current paper and approved the final version of the paper for submission.

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary Material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpsyt.2021.746734/full#supplementary-material

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References

  • 1.APA . Diagnostic and Statistical Manual of Medical Disorders, Vol. 5th ed. Washington, DC: American Psychiatric Association; (2013). [Google Scholar]
  • 2.Ho NF, Li Hui Chong P, Lee DR, Chew QH, Chen G, Sim K. The amygdala in schizophrenia and bipolar disorder: a synthesis of structural MRI, diffusion tensor imaging, and resting-state functional connectivity findings. Harv Rev Psychiatry. (2019) 27:150–64. 10.1097/HRP.0000000000000207 [DOI] [PubMed] [Google Scholar]
  • 3.Lee J, Reavis EA, Engel SA, Altshuler LL, Cohen MS, Glahn DC, et al. fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder. Hum Brain Mapp. (2019) 40:1608–17. 10.1002/hbm.24472 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Van Voorhis AC, Kent JS, Kang SS, Goghari VM, MacDonald AW III, Sponheim SR. Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder. Hum Brain Mapp. (2019) 40:5397–411. 10.1002/hbm.24780 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Misiak B, Stramecki F, Gaweda L, Prochwicz K, Sasiadek MM, Moustafa AA, et al. Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: a systematic review. Mol Neurobiol. (2018) 55:5075–100. 10.1007/s12035-017-0708-y [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Parker DA, Trotti RL, McDowell JE, Keedy SK, Hill SK, Gershon ES, et al. Auditory oddball responses across the schizophrenia-bipolar spectrum and their relationship to cognitive and clinical features. Am J Psychiatry. (2021) 178:952–64. 10.1176/appi.ajp.2021.20071043 [DOI] [PubMed] [Google Scholar]
  • 7.Schretlen DJ, Cascella NG, Meyer SM, Kingery LR, Testa SM, Munro CA, et al. Neuropsychological functioning in bipolar disorder and schizophrenia. Biol Psychiatry. (2007) 62:179–86. 10.1016/j.biopsych.2006.09.025 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Hwang J, Lyoo IK, Dager SR, Friedman SD, Oh JS, Lee JY, et al. Basal ganglia shape alterations in bipolar disorder. Am J Psychiatry. (2006) 163:276–85.163/2/276 [pii] 10.1176/appi.ajp.163.2.276 [DOI] [PubMed] [Google Scholar]
  • 9.Moustafa AA. Cognitive and Behavioral Dysfunction in Schizophrenia. Academic Press; (2021). [Google Scholar]
  • 10.Yoon JH, Minzenberg MJ, Raouf S, D'Esposito M, Carter CS. Impaired prefrontal-basal ganglia functional connectivity and substantia nigra hyperactivity in schizophrenia. Biol Psychiatry. (2013) 74:122–9. 10.1016/j.biopsych.2012.11.018 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Costafreda SG, Fu CH, Picchioni M, Toulopoulou T, McDonald C, Kravariti E, et al. Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder. BMC Psychiatry. (2011) 11:18. 10.1186/1471-244X-11-18 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Gregory R. Bayes Window (4): table of illusions. Perception. (2006) 35:431–2. 10.1068/p3504ed [DOI] [PubMed] [Google Scholar]
  • 13.Rieth CA, Lee K, Lui J, Tian J, Huber DE. Faces in the mist: illusory face and letter detection. Iperception. (2011) 2:458–76. 10.1068/i0421 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Gosselin F, Schyns PG. Superstitious perceptions reveal properties of internal representations. Psychol Sci. (2003) 14:505–9. 10.1111/1467-9280.03452 [DOI] [PubMed] [Google Scholar]
  • 15.Aleman A, Bocker KB, Hijman R, de Haan EH, Kahn RS. Cognitive basis of hallucinations in schizophrenia: role of top-down information processing. Schizophr Res. (2003) 64:175–85. 10.1016/S0920-9964(03)00060-4 [DOI] [PubMed] [Google Scholar]
  • 16.de Boer JN, Linszen MMJ, de Vries J, Schutte MJL, Begemann MJH, Heringa SM, et al. Auditory hallucinations, top-down processing and language perception: a general population study. Psychol Med. (2019) 49:2772–80. 10.1017/S003329171800380X [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Hall JM, O'Callaghan C, Muller AJ, Ehgoetz Martens KA, Phillips JR, Moustafa AA, et al. Changes in structural network topology correlate with severity of hallucinatory behavior in Parkinson's disease. Netw Neurosci. (2019) 3:521–38. 10.1162/netn_a_00078 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Hall JM, O'Callaghan C, Shine JM, Muller AJ, Phillips JR, Walton CC, et al. Dysfunction in attentional processing in patients with Parkinson's disease and visual hallucinations. J Neural Transm. (2016) 123:503–7. 10.1007/s00702-016-1528-3 [DOI] [PubMed] [Google Scholar]
  • 19.Hugdahl K. “Hearing voices”: auditory hallucinations as failure of top-down control of bottom-up perceptual processes. Scand J Psychol. (2009) 50:553–60. 10.1111/j.1467-9450.2009.00775.x [DOI] [PubMed] [Google Scholar]
  • 20.O'Callaghan C, Hall JM, Tomassini A, Muller AJ, Walpola IC, Moustafa AA, et al. Visual hallucinations are characterized by impaired sensory evidence accumulation: insights from hierarchical drift diffusion modeling in Parkinson's disease. Biol Psychiatry Cogn Neurosci Neuroimaging. (2017) 2:680–8. 10.1016/j.bpsc.2017.04.007 [DOI] [PubMed] [Google Scholar]
  • 21.Corlett P, Frith CD, Fletcher P. From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology. (2009) 206:515–30. 10.1007/s00213-009-1561-0 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Daniel C, Lovatt A, Mason OJ. Psychotic-like experiences and their cognitive appraisal under short-term sensory deprivation. Front Psychiatry. (2014) 5:106. 10.3389/fpsyt.2014.00106 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Catalan A, Simons CJ, Bustamante S, Drukker M, Madrazo A, de Artaza MG, et al. Novel evidence that attributing affectively salient signal to random noise is associated with psychosis. PLoS ONE. (2014) 9:e102520. 10.1371/journal.pone.0102520 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Galdos M, Simons C, Fernandez-Rivas A, Wichers M, Peralta C, Lataster T, et al. Affectively salient meaning in random noise: a task sensitive to psychosis liability. Schizophr Bull. (2011) 37:1179–86. 10.1093/schbul/sbq029 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Vercammen A, de Haan EH, Aleman A. Hearing a voice in the noise: auditory hallucinations and speech perception. Psychol Med. (2008) 38:1177–84. 10.1017/S0033291707002437 [DOI] [PubMed] [Google Scholar]
  • 26.Waters F, Collerton D, Ffytche DH, Jardri R, Pins D, Dudley R, et al. Visual hallucinations in the psychosis spectrum and comparative information from neurodegenerative disorders and eye disease. Schizophr Bull. (2014) 40(Suppl. 4):S233–45. 10.1093/schbul/sbu036 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Zeljic K, Xiang Q, Wang Z, Pan Y, Shi Y, Zhou Z, et al. Heightened perception of illusory motion is associated with symptom severity in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. (2021) 104:110055. 10.1016/j.pnpbp.2020.110055 [DOI] [PubMed] [Google Scholar]
  • 28.Zopf R, Boulton K, Langdon R, Rich AN. Perception of visual-tactile asynchrony, bodily perceptual aberrations, and bodily illusions in schizophrenia. Schizophr Res. (2021) 228:534–40. 10.1016/j.schres.2020.11.038 [DOI] [PubMed] [Google Scholar]
  • 29.Baethge C, Baldessarini RJ, Freudenthal K, Streeruwitz A, Bauer M, Bschor T. Hallucinations in bipolar disorder: characteristics and comparison to unipolar depression and schizophrenia. Bipolar Disord. (2005) 7:136–45. 10.1111/j.1399-5618.2004.00175.x [DOI] [PubMed] [Google Scholar]
  • 30.Tam WC, Sewell KW, Deng HC. Information processing in schizophrenia and bipolar disorder: a discriminant analysis. J Nerv Ment Dis. (1998) 186:597–603. 10.1097/00005053-199810000-00002 [DOI] [PubMed] [Google Scholar]
  • 31.Chakrabarty A, Reddy MS. Visual hallucinations in mania. Indian J Psychol Med. (2011) 33:71–3. 10.4103/0253-7176.85399 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32.Keane BP, Silverstein SM, Wang Y, Roche MW, Papathomas TV. Seeing more clearly through psychosis: depth inversion illusions are normal in bipolar disorder but reduced in schizophrenia. Schizophr Res. (2016) 176:485–92. 10.1016/j.schres.2016.06.015 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33.Gupta T, Silverstein SM, Bernard JA, Keane BP, Papathomas TV, Pelletier-Baldelli A, et al. Disruptions in neural connectivity associated with reduced susceptibility to a depth inversion illusion in youth at ultra high risk for psychosis. Neuroimage Clin. (2016) 12:681–90. 10.1016/j.nicl.2016.09.022 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Tam WC, Liu Z. Comparison of neurocognition between drug-free patients with schizophrenia and bipolar disorder. J Nerv Ment Dis. (2004) 192:464–70. 10.1097/01.nmd.0000131805.72855.a3 [DOI] [PubMed] [Google Scholar]
  • 35.Smailes D, Burdis E, Gregoriou C, Fenton B, Dudley R. Pareidolia-proneness, reality discrimination errors, and visual hallucination-like experiences in a non-clinical sample. Cogn Neuropsychiatry. (2020) 25:113–25. 10.1080/13546805.2019.1700789 [DOI] [PubMed] [Google Scholar]
  • 36.Uchiyama M, Nishio Y, Yokoi K, Hirayama K, Imamura T, Shimomura T, et al. Pareidolias: complex visual illusions in dementia with Lewy bodies. Brain. (2012) 135(Pt. 8). 2458–69. 10.1093/brain/aws126 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37.Zhou LF, Meng M. Do you see the “face”? Individual differences in face pareidolia. J Pacific Rim Psychol. (2020) 14. 10.1017/prp.2019.2730886898 [DOI] [Google Scholar]
  • 38.Riekki T, Lindeman M, Aleneff M, Halme A, Nuortimo A. Paranormal and religious believers are more prone to illusory face perception than skeptics and non-believers. Appl Cogn Psychol. (2013) 27:150–5. 10.1002/acp.287425855820 [DOI] [Google Scholar]
  • 39.Partos TR, Cropper SJ, Rawlings D. You don't see what i see: individual differences in the perception of meaning from visual stimuli. PLoS ONE. (2016) 11:e0150615. 10.1371/journal.pone.0150615 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.Epley N, Akalis S, Waytz A, Cacioppo JT. Creating social connection through inferential reproduction: loneliness and perceived agency in gadgets, gods, and greyhounds. Psychol Sci. (2008) 19:114–20. 10.1111/j.1467-9280.2008.02056.x [DOI] [PubMed] [Google Scholar]
  • 41.Iaria G, Fox CJ, Scheel M, Stowe RM, Barton JJ. A case of persistent visual hallucinations of faces following LSD abuse: a functional Magnetic Resonance Imaging study. Neurocase. (2010) 16:106–18. 10.1080/13554790903329141 [DOI] [PubMed] [Google Scholar]
  • 42.Akdeniz G. Brain activity underlying face and face pareidolia processing: an ERP study. Neurol Sci. (2020) 41:1557–65. 10.1007/s10072-019-04232-4 [DOI] [PubMed] [Google Scholar]
  • 43.Wardle SG, Seymour K, Taubert J. Characterizing the response to face pareidolia in human category-selective visual cortex. bioRxiv. (2017) 233387. 10.1101/233387 [DOI] [Google Scholar]
  • 44.Guillon Q, Roge B, Afzali MH, Baduel S, Kruck J, Hadjikhani N. Intact perception but abnormal orientation towards face-like objects in young children with ASD. Sci Rep. (2016) 6:22119. 10.1038/srep22119 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 45.Akdeniz G, Gumusyayla S, Vural G, Bektas H, Deniz O. Changes in face and face pareidolia processing in patients with migraine: an ERP study. J Neurophysiol. (2020) 123:876–84. 10.1152/jn.00549.2019 [DOI] [PubMed] [Google Scholar]
  • 46.Mavrogiorgou P, Peitzmeier N, Enzi B, Flasbeck V, Juckel G. Pareidolias and creativity in patients with mental disorders. Psychopathology. (2021) 54:59–69. 10.1159/000512129 [DOI] [PubMed] [Google Scholar]
  • 47.Ffytche DH, Aarsland D. Psychosis in Parkinson's disease. Int Rev Neurobiol. (2017) 133:585–622. 10.1016/bs.irn.2017.04.005 [DOI] [PubMed] [Google Scholar]
  • 48.Rolf R, Sokolov AN, Rattay TW, Fallgatter AJ, Pavlova MA. Face pareidolia in schizophrenia. Schizophr Res. (2020) 218:138–45. 10.1016/j.schres.2020.01.019 [DOI] [PubMed] [Google Scholar]
  • 49.Andreasen NC, Carpenter WTJr, Kane JM, Lasser RA, Marder SR, Weinberger DR. Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry. (2005) 162:441–9. 10.1176/appi.ajp.162.3.441 [DOI] [PubMed] [Google Scholar]
  • 50.Perlis RH, Ostacher MJ, Patel JK, Marangell LB, Zhang H, Wisniewski SR, et al. Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry. (2006) 163:217–24. 10.1176/appi.ajp.163.2.217 [DOI] [PubMed] [Google Scholar]
  • 51.Leucht S, Samara M, Heres S, Patel MX, Furukawa T, Cipriani A, et al. Dose equivalents for second-generation antipsychotic drugs: the classical mean dose method. Schizophr Bull. (2015) 41:1397–402. 10.1093/schbul/sbv037 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 52.Kaji Y, Kitamura M, Kitagawa N. Do you see something in noise? Your personality traits, emotional state and sex affect your tendency to see pareidolia. In: Paper Presented at the ASSC19. 7-10th July. Paris (2015). [Google Scholar]
  • 53.Mamiya Y, Nishio Y, Watanabe H, Yokoi K, Uchiyama M, Baba T, et al. The pareidolia test: a simple neuropsychological test measuring visual hallucination-like illusions. PLoS ONE. (2016) 11:e0154713. 10.1371/journal.pone.0154713 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 54.Yokoi K, Nishio Y, Uchiyama M, Shimomura T, Iizuka O, Mori E. Hallucinators find meaning in noises: pareidolic illusions in dementia with Lewy bodies. Neuropsychologia. (2014) 56:245–54. 10.1016/j.neuropsychologia.2014.01.017 [DOI] [PubMed] [Google Scholar]
  • 55.First MB, Williams JBW, Karg RS, Spitzer RL. Structured Clinical Interview for DSM-5 Disorders—Clinician Version (SCID-5-CV). Washington, DC: American Psychiatric Association Publishing; (2016). [Google Scholar]
  • 56.Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. (1987) 13:261–76. 10.1093/schbul/13.2.261 [DOI] [PubMed] [Google Scholar]
  • 57.Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. (1960) 23:56–62. 10.1136/jnnp.23.1.56 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 58.Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. (1978) 133:429–35. 10.1192/bjp.133.5.429 [DOI] [PubMed] [Google Scholar]
  • 59.Wechsler D. Wechsler Adult Intelligence Scale, 4th ed. San Antonio, TX: Pearson; (2008). [Google Scholar]
  • 60.Bunney WE, Jr, Hetrick WP, Bunney BG, Patterson JV, Jin Y, Potkin SG, et al. Structured interview for assessing perceptual anomalies (SIAPA). Schizophr Bull. (1999) 25:577–92. 10.1093/oxfordjournals.schbul.a033402 [DOI] [PubMed] [Google Scholar]
  • 61.Kiss I, Fábián Á, Benedek G, Kéri S. When doors of perception open: visual contrast sensitivity in never-medicated, first-episode schizophrenia. J Abnorm Psychol. (2010) 119:586. 10.1037/a0019610 [DOI] [PubMed] [Google Scholar]
  • 62.Perich T, Mitchell P, Moustafa AA. The nature of depression in bipolar disorder. In: Moustafa AA. editors. The Nature of Depression: An Updated Review. Cambridge, MA: Elsevier; (2021). p. 151–67. [Google Scholar]
  • 63.Barrett JL, Lanman JA. The science of religious beliefs. Religion. (2008) 38:109–24. 10.1016/j.religion.2008.01.007 [DOI] [Google Scholar]
  • 64.Leopold DA, Rhodes G. A comparative view of face perception. J Comp Psychol. (2010) 124:233–51. 10.1037/a0019460 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 65.Ancin I, Cabranes JA, Santos JL, Sanchez-Morla E, Barabash A. Executive deficits: a continuum schizophrenia-bipolar disorder or specific to schizophrenia? J Psychiatr Res. (2013) 47:1564–71. 10.1016/j.jpsychires.2013.07.008 [DOI] [PubMed] [Google Scholar]
  • 66.Keshavan MS, Morris DW, Sweeney JA, Pearlson G, Thaker G, Seidman LJ, et al. A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: the Schizo-Bipolar Scale. Schizophr Res. (2011) 133:250–4. 10.1016/j.schres.2011.09.005 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 67.Barch DM, Carter CS, Gold JM, Johnson SL, Kring AM, MacDonald AW, et al. Explicit and implicit reinforcement learning across the psychosis spectrum. J Abnorm Psychol. (2017) 126:694–711. 10.1037/abn0000259 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 68.Lynham AJ, Hubbard L, Tansey KE, Hamshere ML, Legge SE, Owen MJ, et al. Examining cognition across the bipolar/schizophrenia diagnostic spectrum. J Psychiatry Neurosci. (2018) 43:245–53. 10.1503/jpn.170076 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 69.Crespi B, Badcock C. Psychosis and autism as diametrical disorders of the social brain. Behav Brain Sci. (2008) 31:241–61; discussion 261–320. 10.1017/S0140525X08004214 [DOI] [PubMed] [Google Scholar]
  • 70.Baker JT, Holmes AJ, Masters GA, Yeo BT, Krienen F, Buckner RL, et al. Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder. JAMA Psychiatry. (2014) 71:109–18. 10.1001/jamapsychiatry.2013.3469 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 71.Lindenmayer JP, Bossie CA, Kujawa M, Zhu Y, Canuso CM. Dimensions of psychosis in patients with bipolar mania as measured by the positive and negative syndrome scale. Psychopathology. (2008) 41:264–70. 10.1159/000128325 [DOI] [PubMed] [Google Scholar]
  • 72.Saccuzzo DP, Braff DL. Information-processing abnormalities: trait- and state-dependent components. Schizophr Bull. (1986) 12:447–59. 10.1093/schbul/12.3.447 [DOI] [PubMed] [Google Scholar]
  • 73.Serper MR. Visual controlled information processing resources and formal thought disorder in schizophrenia and mania. Schizophr Res. (1993) 9:59–66. 10.1016/0920-9964(93)90010-G [DOI] [PubMed] [Google Scholar]
  • 74.Thakkar KN, Schall JD, Logan GD, Park S. Cognitive control of gaze in bipolar disorder and schizophrenia. Psychiatry Res. (2015) 225:254–62. 10.1016/j.psychres.2014.12.033 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 75.Kim S, Kim YW, Shim M, Jin MJ, Im CH, Lee SH. Altered cortical functional networks in patients with schizophrenia and bipolar disorder: a resting-state electroencephalographic study. Front Psychiatry. (2020) 11:661. 10.3389/fpsyt.2020.00661 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 76.Angst J, Ajdacic-Gross V, Rossler W. Bipolar disorders in ICD-11: current status and strengths. Int J Bipolar Disord. (2020) 8:3. 10.1186/s40345-019-0165-9 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 77.Green E, Toma S, Collins J, Fiksenbaum L, Timmins V, Omrin D, et al. Similarities and differences across bipolar disorder subtypes among adolescents. J Child Adolesc Psychopharmacol. (2020) 30:215–21. 10.1089/cap.2019.0031 [DOI] [PubMed] [Google Scholar]
  • 78.Lopez-Diaz A, Menendez-Sampil C, Perez-Romero A, Palermo-Zeballos FJ, Valdes-Florido MJ. Characterization of deficit schizophrenia and reliability of the bidimensional model of its negative symptomatology. Nord J Psychiatry. (2020) 74:400–6. 10.1080/08039488.2020.1736151 [DOI] [PubMed] [Google Scholar]
  • 79.Tan AS, Chew QH, Sim K. Cerebral white matter changes in deficit and non-deficit subtypes of schizophrenia. J Neural Transm. (2020) 127:1073–9. 10.1007/s00702-020-02207-w [DOI] [PubMed] [Google Scholar]
  • 80.Akdeniz G, Toker S, Atli I. Neural mechanisms underlying visual pareidolia processing: an fMRI study. Pak J Med Sci. (2018) 34:1560–6. 10.12669/pjms.346.16140 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 81.Liu J, Li J, Feng L, Li L, Tian J, Lee K. Seeing Jesus in toast: neural and behavioral correlates of face pareidolia. Cortex. (2014) 53:60–77. 10.1016/j.cortex.2014.01.013 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 82.Watanabe H, Nishio Y, Mamiya Y, Narita W, Iizuka O, Baba T, et al. Negative mood invites psychotic false perception in dementia. PLoS ONE. (2018) 13:e0197968. 10.1371/journal.pone.0197968 [DOI] [PMC free article] [PubMed] [Google Scholar]

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