Table 6.
Predicted amino acid substitution in the LF protein.
| lef Mutation | Predicted Amino Acid Substitution in the Unprocessed LF | Domain of LF | Number of Strains |
|---|---|---|---|
| 196G→A | 66E→K | I, 1α1 | 1 |
| 736G→A | 246V→I | I, 1α9 | 1 |
| 747A→C | - | 1 | |
| 892C→A | 298L→M | II, 2α1 | 4 |
| 895G→A | 299A→T | II, 2α1 | 13 |
| 895G→T | 299A→S | II, 2α1 | 6 |
| 1036C→G | 346Q→E | III, 3α1 *, R2 | 1 |
| 1046A→C | 349K→T | III, 3α1 *, R2 | 3 |
| 1175G→A | 392R→K | III, 3α3, R4 | 1 |
| 1216A→G | 406K→E | III, 3α4, R5 | 3 |
| 1218A→G | - | 3 | |
| 1291T→G | 431L→A | II | 1 |
| 1292T→C | - | 1 | |
| 1294A→G | 432I→V | II | 1 |
| 1305G→A | - | 1 | |
| 1314T→C | - | 1 | |
| 1316T→C | 439L→P | II, 2α4 | 1 |
| 1318G→A | 440D→N | II, 2α4 | 1 |
| 1336A→G | 446K→E | II, 2α4 | 1 |
| 1341G→T | 447R→S | II, 2α4 | 1 |
| 1385G→A | 462S→N | II | 1 |
| 1408T→G | 470L→V | II, 2β1 | 1 |
| 1628G→A | 543R→Q | II, 2β5 | 4 |
| 1688A→C | 563K→T | II, 2β7 | 1 |
| 1689G→A | 564K→T | II, 2β8 | 1 |
| 1695A→G | - | 1 | |
| 1788G→A | - | 1 | |
| 1840A→G | 614K→E | IV | 1 |
| 1854C→G | 618F→L | IV, 4β1 | 1 |
| 1897T→C | 633Y→H | IV, 4α2 | 1 |
| 1901T→C | 634L→S | IV, 4α2 | 1 |
| 1904T→C | 635I→T | IV, 4α2 | 1 |
| 1916G→T | 639W→L | IV, 4α2 | 1 |
| 2030C→A | 677T→K | IV, L2 | 1 |
| 2035C→G | 679Q→E | IV, L2 | 1 |
| 2041G→A | 681E→K | IV, L2 | 4 |
| 2054A→T | 685Q→L | IV, L2 | 1 |
| 2064A→G | - | 1 | |
| 2079T→C | - | 1 | |
| 2084A→C | 695E→A | IV | 1 |
| 2101C→T | 701L→F | IV, 4β4 | 1 |
| 2104C→T | 702H→Y | IV, 4β4 | 1 |
| 2113T→C | 705S→P | IV, 4β4 | 1 |
| 2126A→G | 709E→G | IV | 30 |
| 2128T→A | 710L→I | IV | 1 |
| 2180A→C | 727D→A | IV, 4α4 | 1 |
| 2385T→C | - | 1 |
* synonymous mutation.