REAGENT or RESOURCE	SOURCE	IDENTIFIER
Software and algorithms
MPF-BML standalone package	Louie et al. (2018); Quadeer et al. (2020)	https://github.com/ahmedaq/MPF-BML-GUI
DCA	Morcos et al. (2011)	http://dca.rice.edu/portal/dca/home
PyMOL	Schrödinger, Inc.	https://www.pymol.org
Other
Fitness landscape and the mean escape time predicted by the in-host evolutionary model for each residue of E2 subtype 1a	Quadeer et al. (2019a)	https://github.com/ahmedaq/HCV-E2
The E2 subtype 1b infectivity measurements, used for validating the fitness landscape model	This manuscript	Data S1
Accession numbers of E2 subtypes 1b sequences used for inferring the model	This manuscript	Data S2
The mean escape time predicted by the in-host evolutionary model for each residue of E2 subtype 1b	This manuscript	Data S3
Data and scripts for reproducing the results reported in the manuscript	This manuscript	https://github.com/hangzhangust/HCVE21a1b