Table 2.

Genes and Their Role in Severity. A list of the top genes and their function in disease severity.

Factors of Severity	Genes and Function
Decreased Immune Response	HLA-A, -B, -C—immune regulatory genes NCAM1—decreased immune cell expansion and interferon signaling
Factors that Correlate with Severity	APOB—decreased apolipoproteins COVID-19 patient plasma B2M—decreased organ expression contributes to renal and cardiovascular damage
Fibrosis	ACTA1—pro-fibrotic factor
Increased Hypercytokinemia	ALCAM—increased cytokine production FHL1—increased cytokine translation
Increased Viral Transcription and Translation	CA12—translational control SYNE2—contributes to cell cycle regulation
Multi-Organ Failure	PCDH9—cadherin disruption decreases endothelial barrier integrity
Organ Specific Damage	HSPA1A—ischemia and kidney damage PDE3B—induces angiogenesis, contributes to ARDS SGCD—related to cardiomyopathy SLC39A14—related to ferroptosis in liver