Table 5.
Acute oral toxicity and therapeutic index of the extracts from A. muricata leaves.
| Treatment | LD50 (mg kg−1) | TIa | Treatment | LD50 (mg kg−1) | TI a |
|---|---|---|---|---|---|
| AcFe | 1585 | 119.2 | TeFe | 1585 | 97.8 |
| AcAp | 1585 | 76.2 | TeAp | 1585 | 52.5 |
| AcJu | 165 | 6.7 | TeJu | 232 | 13.7 |
| AcAg | 165 | 4.1 | TeAg | 232 | 11.2 |
| AcOc | 1515 | 97.1 | TeOc | 1585 | 110.1 |
| AcDe | 1515 | 140.7 | TeDe | 1585 | 131.0 |
Correlation coefficient > 0.9500; Data are expressed as mean ± S. E. M. (n = 3); LD50: Lethal dose 50. a TI: therapeutic index calculated as LD50 (acute oral toxicity)/ED50 (antitumor activity).