Figure 12.

Clasping response (A) and rotarod performance (B) analyzed TDP-43 transgenic and wild-type male mice at specific weeks during a chronic treatment of 30 days with VCE-006.1 (20 mg/kg, daily and i.p.) or vehicle, and quantification of the number of Nissl-stained motor neurons (D), including representative images ((C); scale bar = 100 µm), in the lumbar ventral horn (marked with a dotted line) of the spinal cord in all experimental groups after the chronic treatment. Values are means ± SEM of more than 6 animals per group. Behavioral data were assessed by two-way ANOVA (with repeated measures), whereas Nissl staining data were assessed by one-way ANOVA, in both cases followed by the Tukey test (* p < 0.05, ** p < 0.01, *** p < 0.005 vs. wild-type mice; ^# p < 0.05 vs. TDP-43 mice treated with vehicle).