Table 1.

List of detected complement fragments.

Peptide ID	Sequence	Complement	Start AA	Stop AA	Avg. rel. abund.	rho eGFR	p-Value eGFR	rho PU	p-Value PU
e13403	FLSSLTETIEGVDAEDGHGPGEQQ	CFB	234	257	51.86	−0.053	0.5059	0.174	0.0482
e11594	LSSLTETIEGVDAEDGHGPGEQ	CFB	235	256	186.82	0.19	<0.0001	−0.06	0.0276
e11703	SSLTETIEGVDAEDGHGPGEQQ	CFB	236	257	79.35	0.236	<0.0001	−0.133	0.0565
e12606	LSSLTETIEGVDAEDGHGPGEQQ	CFB	236	257	876.10	−0.044	0.0069	0.074	0.0004
e10517	LTETIEGVDAEDGHGPGEQQ	CFB	238	257	59.02	0.298	<0.0001	−0.178	<0.0001
e08566	TETIEGVDAEDGHGPGEQ	CFB	239	256	434.59	0.269	<0.0001	−0.203	<0.0001
e09682	TETIEGVDAEDGHGPGEQQ	CFB	239	257	109.77	0.377	<0.0001	−0.063	0.1778
e08161	TLTKAPADLRGVAHNNL	C4B	1201	1217	51.00	0.056	0.2757	−0.012	0.8334
e06142	TKAPADLRGVAHNNL	C4B	1203	1217	98.92	−0.175	<0.0001	0.224	<0.0001
e09265	DELPAKDDPDAPLQPVTP	C4B	1423	1440	134.67	0.299	<0.0001	−0.261	<0.0001
e08035	TLTKAPVDLLGVAHNNL	C4A	1201	1217	74.57	0.123	0.0422	−0.08	0.2586
e03984	APVDLLGVAHNNL	C4A	1205	1217	22.80	0.063	0.5361	0.051	0.6521
e00117	LGVAHNNL	C4A	1210	1217	116.12	−0.041	0.1899	0.326	<0.0001
e09429	EGVQKEDIPPADLSDQVP	C3	955	972	882.83	−0.156	0.0001	0.254	<0.0001
e16041	EGVQKEDIPPADLSDQVPDTESETRIL	C3	955	981	169.49	0.059	0.0028	0.038	0.1365
e17084	EGVQKEDIPPADLSDQVPDTESETRILLQ	C3	955	983	56.92	0.356	<0.0001	−0.176	<0.0001
e18666	EGVQKEDIPPADLSDQVPDTESETRILLQGTPVA	C3	955	988	4.08	0.126	0.1361	−0.17	0.1261
e12939	LQGTPVAQMTEDAVDAERLKHL	C3	982	1003	3066.93	−0.213	<0.0001	0.445	<0.0001
e06787	IGGLRNNNEKDMALT	C3	1130	1144	154.90	−0.005	0.8695	0.103	0.0147
e14381	LTTAKDKNRWEDPGKQLYNVEAT	C3	1211	1233	79.81	−0.28	<0.0001	0.278	<0.0001
e16109	LTTAKDKNRWEDPGKQLYNVEATSYA	C3	1211	1236	74.69	−0.148	0.0264	0.148	0.0524
e09686	QALAQYQKDAPDHQELN	C3	1277	1293	152.22	−0.23	<0.0001	0.359	<0.0001
e08849	YQKDAPDHQELNLDVS	C3	1282	1297	80.10	−0.021	0.7393	0.082	0.2554

Given are an identification number (ID), amino acid sequence, parental complement protein, peptide position in the protein sequence, and average relative abundance of these peptides calculated based on the full dataset of 16,027 individuals, along with correlation coefficient (rho) with eGFR and proteinuria (PU) of complement fragments together with the respective p-value. Abbreviations: AA: amino acid; Avg. rel. abund.: Average relative abundance; C3: Complement C3; C4B: Complement 4B; CFB: Complement Factor B; eGFR: estimated glomerular filtration rate; PU: proteinuria; rho: Spearman’s Rank Correlation Coefficient.