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The structure of the SARS-CoV-2 virus and the interference of multiple activity of bromelain (B) in the crucial steps of COVID-19 pathophysiology. TMPRSS2, transmembrane serine protease 2; ACE2, angiotensin-converting enzyme II receptor; IL-1β, interleukin 1 beta; IL-6, interleukin 6; TNF-α, tumor necrosis factor-alpha; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; COX-2, cyclooxygenase 2; PGE-2, prostaglandin E-2; PGI2, prostacyclin.
