Table 3.

Biological signatures associated to H3K27me3-regulated promoters on gastrocnemius X chromosome. Results of an ingenuity pathway analysis for promoters differentially marked by H3K27me3 in X chromosome from PSAPP gastrocnemius are reported. Only terms with an activation z-score above |2| are taken in consideration. All the results are presented as regulated (increased/decreased) in females with respect to males.

Gastrocnemius Diseases or Functions (H3K27me3 X)	p-Value	Predicted Activation State	Activation Z-Score	Molecules	N° of Molecules
Organization of actin cytoskeleton	27.23 × 10−3	Increased	2.000	ARHGAP4,EFNB1,FGD1,GPM6B,MSN,OPHN1,PAK3,PLS3, Tmsb4x (includes others)	9
Abdominal cancer	1.41 × 10−5	Decreased	−2.000	ABCB7,ACE2,AIFM1,AMER1,ARHGAP36,ARHGAP4,ARHGEF9, ARMCX1,ARMCX2,ARMCX3,ARMCX4,ARMCX5,ARX, ASB9, ATP2B3,AVPR2,AWAT2,BCOR,BCORL1,BEX1,BGN, BMX,BRS3, BTK,CA5B,CACNA1F,CCDC160,CD40LG, CDX4,CHRDL1, CLDN2,CNGA2,CNKSR2,COL4A5,DACH2,DCAF12L2,DGAT2L6,DOCK11, DUSP9, EFNB1,EGFL6,ELF4,ERCC6L,FAM155B, FGD1,FOXO4,FOXR2,FRMD7,FRMPD3,GABRA3,GABRQ,GATA1, GDPD2,GJB1,GPC3,GPC4,GPM6,GPR101,GPR143, GPR50,GRIA3, GRPR,GSPT2,GUCY2F,HCFC1,HDAC8, HPRT1,HSD17B1,HTR2C, IDH3G,IGSF1,IL13RA1,IL1RAPL1,IL1RAPL2, IQSEC2,IRAK1, KCND1,KCNE5,KLF8,KLHL15,L1CAM, LANCL3,LHFPL1, LONRF3,MAGEA10, MAGEA11,MAGED1,MAGEE1,MAGEE2, MAP7D2,MBNL3,mir-452,MSN,NAA10,NAP1L2,NEXMIF,NONO, NRK,NYX,OGT,OPHN1,OPN1LW,OTUD6A,PAK3,PCDH11X, PCDH19,PDK3,PDZD4,PHF6,PHKA1,PLAC1,PLS3,PLXNA3, PLXNB3,PNMA3,PNMA5,PRKX,PRPS1,PRPS2,PTCHD1, RAB33A, RAI2,RAP2C,RBM41,RNF128,RPS4Y1,RRAGB,SLC16A2,SLC25A43,SLC38A5,SLC6A8,SLC7A3,SLITRK4,SOWAHD,SOX3,SRPX, STARD8,SYN1,SYTL4,TAB3,TAF1,TBX22,TCEANC,THOC2, TMEM164,TMEM255A,TMEM47,TREX2, TRPC5,TSC22D3,TSPYL2, UPF3B,USP51,UTP14A,VGLL1,YIPF6,ZC4H2, ZCCHC12, ZDHHC9,ZFX,ZIC3,ZMYM3	162