Table 6.

Prevalence of any known mutations in pancreatitis susceptibility genes in controls and CP patients of EA and AA in the NAPS2 Cohort.

%	Controls		CP (all)		CP (alcohol etiology)		CP (no alcohol etiology)
	European (n = 610)	African American (n = 238)	European (n = 862)	African American (n = 232)	European (n = 362)	African American (n = 178)	European (n = 500)	African American (n-54)
Mutation (1 or more) present in any of the four genes	14.92*	6.72	29.00*	8.19	22.38*	7.87	33.80*	9.26
Any mutation present in PRSS1 gene	0.16	0.00	4.87*	0.86	1.38	0.56	7.40	1.85
SPINK1 (N34S) mutation present	2.46*	0.00	9.40*	1.72	7.73*	2.25	10.60	0.00
Any mutation in CFTR gene:
CFTR total	12.13*	6.30	17.87*	5.17	14.92*	5.06	20.00*	5.56
CFTR sev	3.11	2.10	8.12*	1.29	5.25	1.12	10.20	1.85
CFTR BD	9.34	4.20	10.21*	4.31	9.67	4.49	10.60	3.70
Any mutation in the CTRC gene	0.33	0.42	1.28	0.43	1.38	0.00	1.20	1.85

Results for mutations are presented as proportions.

^*p < 0.05 for any mutation; comparisons for individual genes (p < 0.0125 – after Bonferroni adjustment for 4 comparisons).

AA – African ancestry; CP – chronic pancreatitis; EA – European ancestry; NAPS2 – North American Pancreatitis Study.