Table 2: Serotonin Transporter Availability in Late-Life Depressed (LLD) Patients Scanned Prior to Starting Antidepressant Treatment Compared to Demographically-Matched Controls: Volume of Interest Analysis (VOI).

Sample Size (Healthy Controls: n=20; LLD patients n=20).

	Healthy Controls	LLD Patients	F Ratio	P Value	Effect Size
BPnd for [¹¹C]- DASB VOI’s
Cortical Regions
Cingulate Gyrus	0.54 ± 0.16	0.51 ±0.12	0.39	0.537	−0.21
Frontal Cortex	0.33 ± 0.11	0.32 ±0.10	0.20	0.659	−0.10
Temporal Lobe	0.32 ± 0.08	0.27 ±0.09	3.24	0.080	−0.58
Pre-central Gyrus	0.30 ± 0.10	0.32 ±0.12	0.24	0.624	0.18
Post-Central Gyrus	0.33 ± 0.12	0.34 ±0.14	0.08	0.772	0.08
Parietal Lobe	0.29 ±0.09	0.31 ±0.11	0.62	0.435	0.19
Occipital Lobe	0.36 ±0.08	0.34 ±0.12	0.37	0.548	−0.20
Insula	0.76 ±0.17	0.70 ±0.14	1.76	0.193	−0.37
Sub-Cortical Regions
Caudate	1.17 ±0.33	0.97 ±0.28	4.16	0.048	−0.63
Putamen	1.67 ±0.33	1.56 ±0.24	1.61	0.212	−0.38
Globus Pallidus	1.51 ±0.33	1.40 ±0.30	1.15	0.289	−0.35
Ventral Striatum	1.77 ±0.35	1.65 ±0.22	1.82	0.185	−0.40
Thalamus	1.46 ±0.28	1.39 ±0.26	0.61	0.439	−0.26
Brainstem	1.06 ±0.18	0.97 ±0.24	1.68	0.203	−0.42
Limbic Regions
Amygdala	1.48 ±0.25	1.33 ± 0.28	3.38	0.074	−0.55
Hippocampus	0.52 ±0.13	0.43±0.12	4.88	0.033	−0.69
Entorhinal Cortex	0.56 ±0.13	0.39±0.15	15.03	0.000	−1.03
Parahippocampal Gyrus	0.46 ±0.12	0.36±0.12	7.18	0.011	−0.78