The Log of serum GFAP (a), NFL (b), NSE (c), S100B (d), total-tau (e) and UCH-L1 (f) concentration by CT pathology. Violin plots and boxplots provide median, range and 25-75th percentile of the log10 biomarker concentration per pathoanatomical grouping/isolated lesion type: (No acute abnormality (n=1069), Skull fracture (n=86), EDH (n=47), Acute SDH (n=89), SAH (n=184), IPH (n=41), DAI (n=31), Mixed Lesion (n=1313). P values determined by the Dunn Kruskal-Wallis test with Benjamini-Hochberg correction for multiple comparisons was used for group wise comparison across different CT findings. Significance levels are displayed for statistically significant group wise comparisons, * = p< 0·05, ** = p< 0·01, *** = p< 0·001. Patients with mixed lesion on CT (defined as 2 or more lesions types) (n=1362) and those with isolated mixed density SDH (n=9) are not included as a boxplot.