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. Author manuscript; available in PMC: 2021 Dec 31.
Published in final edited form as: Nature. 2021 Mar 17;592(7854):421–427. doi: 10.1038/s41586-021-03343-3

Extended Data Figure 6 |. Generation of hCS and cCS and RNA-sequencing.

Extended Data Figure 6 |

a-b, Representative bright field images of three CS per line for three human (a) and three chimpanzee (b) cell lines at day 166. c, Immunostaining of hCS and cCS for SOX9, PAX6 and CTIP2; at each time point, a maximum of 2 spheroids were fixed for immunostaining across 3 hiPS and 3 ciPS cell lines with 4 independent differentiation experiments per cell line. d-e, Heatmap of correlations (Pearson’s) between bulk RNA-seq samples for hCS (d) and cCS (e). Scale bars, 1 mm (a-b), 50 μm (c).